Table 3 BreastMark results for the Oncotype DX 21-gene signature for LNN, ER-positive patients using DFS as the survival end point
OncotypeDX category | Gene symbol | BreastMark hazard ratio | BreastMarkHR P-value | Sample number | RS weighting |
|---|---|---|---|---|---|
Proliferation | KI67 | 1.68 | 4.40e-05 | 902 | +1.04 |
| Â | STK15 | 2.32 | 3.93e-11 | 902 | Â |
| Â | Survivin | 1.96 | 8.56e-08 | 902 | Â |
| Â | CCNB1 | 1.89 | 3.63e-06 | 793 | Â |
| Â | MYBL2 | 1.76 | 8.01e-06 | 902 | Â |
Invasion | MMP11 | 1.55 | 1.00e-03 | 875 | +0.1 |
| Â | CTSL2 | 1.42 | 7.12e-03 | 875 | Â |
HER2 | GRB7 | 1.26 | 0.07 | 902 | +0.47 |
| Â | HER2 | 1.03 | 0.83 | 875 | Â |
ER | ER | 1.32 | 0.05 | 875 | -0.34 |
| Â | PGR | 0.80 | 0.08 | 902 | Â |
| Â | BCL2 | 0.75 | 0.03 | 875 | Â |
| Â | SCUBE2 | 0.71 | 0.03 | 628 | Â |
Other | GSTM1 | 0.92 | 0.56 | 651 | -0.08 |
| Â | CD68 | 0.96 | 0.74 | 902 | +0.05 |
| Â | BAG1 | 1.01 | 0.91 | 902 | -0.07 |