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Figure 2 | Breast Cancer Research

Figure 2

From: Elevated expression of syntenin in breast cancer is correlated with lymph node metastasis and poor patient survival

Figure 2

Effect of syntenin on breast cancer cell migration and invasion in vitro. (A, B) Cell migration assessed by scratch assay. Representative area of cells at 48 hours after scratch assay is shown. (C, D) Migration assay. (E, F) Invasion assay. (C, E) Overexpression of syntenin promoted breast cancer cell migration (C) and invasion (E). (D, F) The migrated or invaded cells were significantly reduced after syntenin knockdown in MDA-MB-231HM cells. Cells were plated on noncoated or gelatinous protein (Matrigel)-coated filters for migration or invasion assay, respectively. Cells that migrated or invaded through the pores in the filter were fixed, stained, and counted in five random fields visualized with microscopy (200×). Data represent mean ± SD of three independent experiments performed in triplicate. **P < 0.01; ***P < 0.001.

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Breast Cancer Research

ISSN: 1465-542X

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