The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors

Table 1 Phosphorylated Akt^Ser473 expression between BCSCs and non-BCSCs from primary human breast cancer specimens

	Expression level of p-Akt^Ser473 (%, MFI)^a
	BCSCs (CD45^-CD24^-CD44⁺)	Non-BCSCs (other populations of CD45^- cells)	Ratio^b (BCSCs/non-BCSCs)
BC0414	33.3 (9.7)	17.5 (9.4)	1.90
BC0417	41.8 (32.0)	29.0 (33.0)	1.44
BC0422	32.4 (16.9)	14.3 (25.2)	2.27
BC0426	23.3 (5.2)	22.6 (5.7)	1.03
BC0450	41.3 (10.3)	56.2 (13.9)	0.73
BC0466	56.7 (36.5)	40.8 (44.1)	1.39
BC0480	55.7 (11.8)	37.8 (9.6)	1.47
BC0485	33.0 (44.2)	43.4 (54.8)	0.76
BC0512	57.8 (66.7)	37.8 (38.2)	1.53
BC0526	53.9 (28.2)	50.8 (34.4)	1.06
BC0533	47.8 (33.8)	0	∞

BSCS, breast cancer stem cell; MFI, mean fluorescence intensity ^ap-Akt^Ser473 expression was determined by flow cytometry as described in Materials and methods. ^bThe ratio was calculated according to the positive percentage of pAkt^Ser473 in BCSCs and non-BCSCs.

ISSN: 1465-542X