Relationship of serum estrogens and estrogen metabolites to postmenopausal breast cancer risk: a nested case-control study

Table 2 Medians and inter-decile ranges, estrogen metabolites^a cases and controls, Columbia MO Serum Bank Cohort Breast Cancer Study

	Cases			Controls
	Median	Inter-decile range		Median	Inter-decile range
Parent Estrogens	50%	10%	90%	50%	10%	90%
Estrone
total	252.76	108.7	676.4	226.76	96.5	842.7
conjugated	203.25	75.1	577.6	183.25	68.7	741.1
unconjugated	46.62	25.5	85.5	43.47	22.8	97.5
Estradiol
total	26.80	11.4	72.0	22.94	10.1	105.7
conjugated	13.73	5.0	40.8	12.06	4.9	45.2
unconjugated	11.19	4.5	36.3	10.02	4.1	41.3
2-Pathway
2-hydroxyestrone	75.30	64.4	136.5	73.92	64.7	155.0
2-hydroxyestradiol	12.21	12.2	46.3	22.96	12.5	50.3
2-methoxyestrone
total	43.65	7.4	84.2	41.42	22.3	100.4
conjugated	23.85	7.4	55.0	25.15	9.2	59.4
unconjugated	16.38	6.7	43.5	15.33	5.7	42.5
2-methoxyestradiol
total	13.53^	6.4	29.4	15.68	6.9	37.6
conjugated	9.91^	3.7	25.7	11.40	4.3	36.0
unconjugated	2.51	1.0	7.9	2.16	0.9	8.0
2-methoxyestrone,3-methyl ether	5.63	1.9	16.9	6.58	2.2	16.5
4-Pathway
4-hydroxyestrone	19.99	14.1	33.2	17.61	13.4	36.7
4-methoxyestrone	3.48	1.0	7.4	3.60	1.3	7.3
4-methoxyestradiol	1.89	1.0	5.3	1.97	1.0	5.5
16-Pathway
16α-hydroxyestrone	37.87	27.8	72.9	37.25	27.5	85.0
Estriol
total	283.29	167.2	580.9	271.98	163.4	624.7
conjugated	245.97	131.8	536.9	227.52	126.4	598.7
unconjugated	32.69	8.1	84.8	26.71	7.8	73.7
16-ketoestradiol	32.05	20.6	64.0	31.59	19.3	76.7
16-epiestriol	5.97	2.3	20.5	5.50	1.9	19.0
17-epiestriol	2.21	1.1	8.1	2.33	1.0	7.5
Total EM	837.91	540.4	1777.9	802.76	512.7	2151.8

^apmol/l. ^P <0.05, Wilcoxon rank sum test of differences between cases and controls.

ISSN: 1465-542X