Figure 3
Mechanisms of AGR2 activation and subsequent cellular effects of AGR2 expression. Green molecules represent activators of AGR2 expression, and red molecules represent inhibitors. Blue proteins represent targets that AGR2 works through to mediate tumor progression, metastasis, drug resistance, invasion, cell survival, and cell proliferation. AREG, amphiregulin; AGR2, anterior gradient 2; C4.4A, LY6/PLAUR domain containing 3; CTSB/D, cathepsin B and cathepsin D; DAG1, dystroglycan 1; EBP1, ErbB3-binding protein 1; EGFR, epidermal growth factor receptor; ER, estrogen receptor, ERet, endoplasmic reticulum; FOXA, forkhead box family members A1 and A2; HSP90, heat-shock protein 90; Tam, tamoxifen; TGF-β, transforming growth factor-beta; YAP1, yes-associated protein 1.