Figure 1

Overexpression of AGR2 and AGR3 in the ER-positive luminal A and B breast cancer subtypes. (a) Primary breast tumor gene expression data from three independent studies [29–31] with a total of 1,169 samples were log2-normalized and mean centered and then combined into one large data set. AGR2 is expressed significantly higher in the ER-positive luminal A (LumA) and B (LumB) subtypes and is lowly expressed in the ER-negative basal-like (Basal), Her2, and normal breast-like (Normal-Like) tumors. (b) AGR3 gene expression was analyzed in the same way as AGR2 and similarly was expressed significantly higher in LumA and LumB tumors. *P <0.05; **P <0.01; ****P <0.0001. AGR2, anterior gradient 2; ER, estrogen receptor; ns, not significant.