Expression of quiescin sulfhydryl oxidase 1 is associated with a highly invasive phenotype and correlates with a poor prognosis in Luminal B breast cancer

Table 1 Statistical assessment of QSOX1 protein expression with molecular subtypes of breast cancer

		IHC Score			P-value
	No QSOX1 staining (n= 17) %	Low QSOX1 staining (n= 47) %	Intermediate QSOX1 staining (n= 24) %	High QSOX1 staining (n= 65) %
Grade					*0.0003
1	53.3	42.2	25	10.8
2	33.3	33.3	41.7	32.3
3	13.3	24.4	33.3	56.9
ER					*0.0013
ER +	80	89.1	73.9	55.4
ER -	20	10.9	26.1	44.6
HER2					0.0811
HER2 +	11.8	6.4	29.2	14.1
HER2 -	88.2	93.6	70.8	85.9
CK5/6					0.0733
CK5/6 -	100	95.7	87.5	83.1
CK5/6 +	0	4.3	12.5	17
KI-67					*0.0011
Low	33.3	33.3	41.1	18.5
Intermediate	44.4	45.5	17.7	16.7
High	22.3	21.2	41.2	64.8
ER & HER2					*0.0016
ER- HER2 -	13.3	8.7	8.7	35.9
Others	86.7	91.3	91.3	64.1
ER, HER2 and CK5/6					0.0923
ER- HER2-, CK5/6: 1/2/3	0	4.3	4.2	15.4
Others	100	95.7	95.8	84.6

QSOX1 expression was grouped into four categories based on the percentage of cells stained and the intensity of QSOX1 expression: No expression, Low QSOX1 expression, Moderate QSOX1 expression and Strong QSOX1 expression (see material and methods for detailed explanation). Each number represents the percentage of QSOX1 positive or negative cells within each molecular subtype of breast cancer (n = total number of tissue samples within each category). Pearson's chi-square test was performed to determine a relationship between the molecular subtypes and QSOX1 expression. Statistical significance using a two-sided P-value was set at P ≤0.05*.

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