| Fulvestrant 500 mg | Fulvestrant 500 mg + anastrozole 1 mg | Anastrozole 1 mg |
---|---|---|---|
ER | |||
   n | 35 | 31 | 37 |
   Pre-treatment mean H-score | 187.7 | 184.2 | 192.2 |
   Post-treatment mean H-score | 111.9 | 115.8 | 164.2 |
   Change (post-treatment), % (SEM) | -41 (4) | -39 (5) | -13 (4) |
   Comparison versus baseline | P = 0.0001 | P = 0.0001 | P = 0.0034 |
PgR | |||
   n | 33 | 28 | 33 |
   Pre-treatment mean H-score | 145.7 | 141.7 | 157.6 |
   Post-treatment mean H-score | 97.9 | 81.1 | 93.8 |
   Change (post-treatment), % (SEM) | -34 (6) | -45 (7) | -37 (6) |
   Comparison versus baseline | P = 0.0001 | P = 0.0001 | P = 0.0001 |
Ki67 | |||
   n | 35 | 31 | 37 |
   Pre-treatment mean index | 17.1 | 17.8 | 16.2 |
   Post-treatment mean index | 4.2 | 3.3 | 2.6 |
   Change (post-treatment), % (SEM) | -75 (9) | -81 (7) | -85 (5) |
   Comparison versus baseline | P = 0.0001 | P = 0.0001 | P = 0.0001 |