Figure 7
From: Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer
High-resolution magic angle spinning magnetic resonance spectroscopy demonstrates changes in glucose and choline metabolism. Example spectra from basal-like xenografts illustrate changes in (A) glucose and (B) choline metabolites. BEZ235 treatment (blue spectra) increased the glucose concentration compared with vehicle control (red spectra). A concomitant decrease in lactate concentration was observed. Both glycerophosphocholine (GPC) and phosphocholine (PCho) concentrations were also increased after BEZ235 treatment.