Phosphatidylinositol 3-kinase inhibition induces changes in glucose and choline metabolism. (A), (C) In basal-like xenografts, treatment with phosphatidylinositol 3-kinase (PI3K) inhibitors increased the concentration of phosphocholine (PCho; both MK-2206 and BEZ235) and glycerophosphocholine (GPC; BEZ235 only). BEZ235 caused an increase in the glucose concentration, whereas both MK-2206 and BEZ235 reduced the lactate concentration. (B), (D) No treatment-related changes in these metabolites were observed in luminal-like xenografts. *Significantly different from control (P <0.05).