Figure 5
From: Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer
Reduced pAktser473 levels are correlated with tumor growth inhibition and reduced proliferation in basal-like xenografts. (A) Mitotic activity (phosphohistone H3 (PHH3) counts/10 fields of view) in basal-like and luminal-like xenografts after treatment with MK-2206 and BEZ235. (B) Correlation between pAktser473 signal intensity and mitosis in basal-like xenografts treated with vehicle (open squares), MK-2206 (filled circles) and BEZ235 (open triangles). (C) Tumor volumes (relative to day 0) in basal-like xenografts treated with MK-2206 (filled circles) and BEZ235 (open triangles), compared with vehicle-treated controls (open squares). (D) Tumor volumes (relative to day 0) in luminal-like xenografts treated with MK-2206 (filled circles) and BEZ235 (open triangles), compared with vehicle-treated controls (open squares).