Optical imaging correlates with magnetic resonance imaging breast density and revealscomposition changes during neoadjuvant chemotherapy

Table 2 Absolute tissue concentrations (mean ± standard error) measured in thenormal breast at baseline

	Water (%)	Lipid (%)	ctO₂Hb (µM)	ctHHb (µM)	ctTHb (µM)	stO₂ (%)	TOI
All n = 28	21.4 ± 1.3	69.7 ± 1.3	18.0 ± 1.2	5.0 ± 0.2	23.0 ± 1.3	77.2 ± 0.9	1.7 ± 0.2
Pre n = 17	24.4 ± 1.8^c	67.0 ± 1.6^b	18.9 ± 1.7	5.3 ± 0.2^a	24.2 ± 1.9	76.8 ± 1.1	2.1 ± 0.3^b
Post n = 11	16.6 ± 0.7^c	74.0 ± 1.4^b	16.6 ± 1.5	4.5 ± 0.2^a	21.1 ± 1.6	77.7 ± 1.7	1.0 ± 0.1^b

Data are shown for all patients, and for the premenopausal (pre) andpostmenopausal (post) subgroups. ctO₂Hb, oxyhemoglobinconcentration; ctHHb, deoxyhemoglobin concentration; ctTHb, total hemoglobinconcentration; stO₂, tissue oxygen saturation; TOI, tissue opticalindex. ^a,b,cA statistically significant difference (Mann-WhitneyU test) between pre- and postmenopausal groups (P <0.05; P < 0.01; P < 0.001, respectively).

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