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Table 4 Additional specificity testing of aberrantly methylated genes in colon cancer in the test and validation sets

From: Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening

  Specificity in colon cancer
  Test set Validation set
Gene Methylation
negative
% Methylation
negative
%
DKK3 27 of 27 100 24 of 31 77
ITIH5 24 of 27 89 22 of 31 71
WIF1 23 of 27 85 n.d.  
SFRP1 16 of 22 73 n.d.  
SFRP2 22 of 26 85 n.d.  
SFRP5 n.d.   n.d.  
RASSF1A n.d.   13 of 31 42
DKK3/ITIH5 a 24 of 27 88 16 of 31 52
Three-gene panela n.d.   6 of 31 19
  1. aEither gene methylated. n.d., not done.