Skip to main content

Advertisement

Table 2 Detection of aberrant gene promoter methylation in paired samples (serum and tumor) in the test set

From: Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening

  Sensitivity in
breast cancer serum
Sensitivity in
breast cancer tissue
Gene Methylation
Positive
% Methylation
positive
%
ITIH5 27 of 112 24 81 of 112 72
DKK3 37 of 112 33 97 of 112 87
WIF1 39 of 112 35 108 of 112 96
SFRP1 12 of 112 11 89 of 111 79
SFRP2 21 of 112 19 90 of 112 80
SFRP5 9 of 112 8 104 of 110 93
DKK3/ITIH5 a 46 of 112 41 105 of 112 94
  1. aEither gene methylated.