|  | Observed risk (%) | Assigned risk (%) | Observed/Assigned | |||
---|---|---|---|---|---|---|---|
All subjects | N | Risk | CI | BCRAT | IBIS | BCRAT | IBIS |
Age (yrs) at risk assignment | Ratio | Ratio | |||||
<35 | 471 | 1.91 | 0.91-3.98 | 0.58 | 2.11 | 3.29 | 0.91 |
35-49 | 769 | 7.03 | 5.06-9.68 | 2.96 | 6.13 | 2.38 | 1.15 |
50+ | 617 | 8.49 | 6.16-11.59 | 5.43 | 7.26 | 1.56 | 1.17 |
Age (yrs) at first menarche | |||||||
<14 yrs | 1416 | 6.67 | 5.24-8.47 | 3.31 | 5.64 | 2.02 | 1.18 |
> = 14 or unknown | 441 | 4.54 | 2.74-7.45 | 2.74 | 4.98 | 1.66 | 0.91 |
Age (yrs) at FLB | |||||||
<25 yrs | 576 | 4.98 | 3.15-7.79 | 4.05 | 4.93 | 1.23 | 1.01 |
> = 25 or Nulliparous | 1281 | 6.71 | 5.23-8.58 | 2.79 | 5.73 | 2.41 | 1.17 |
Menopausal status | |||||||
Pre | 1190 | 5.13 | 3.77-6.94 | 2.04 | 4.51 | 2.51 | 1.14 |
Post | 667 | 8.13 | 5.95-11.00 | 5.2 | 7.22 | 1.56 | 1.13 |
HRT use | |||||||
Never | 1488 | 5.59 | 4.3-7.24 | 2.79 | 5.07 | 2.00 | 1.10 |
Ever | 369 | 8.56 | 5.74-12.60 | 4.74 | 7.16 | 1.81 | 1.20 |
Number of breast biopsies | |||||||
0 | 1546 | 5.72 | 4.42-7.36 | 2.63 | 5.04 | 2.17 | 1.13 |
1+ | 311 | 8.7 | 5.72-13.02 | 5.87 | 7.72 | 1.48 | 1.13 |
BMI (kg/m²) | |||||||
<25 | 1098 | 5.80 | 4.36-7.67 | 2.98 | 5.25 | 1.95 | 1.05 |
> = 25 | 759 | 7.04 | 4.99-9.85 | 3.46 | 5.83 | 2.03 | 1.21 |
First-degree female relatives with BC | |||||||
0 | 641 | 5.84 | 3.93-8.61 | 1.67 | 3.43 | 3.50 | 1.70 |
1+ | 1261 | 6.48 | 4.98-8.38 | 3.97 | 6.57 | 1.63 | 0.99 |
Second/third-degree relatives with BC | |||||||
0 | 969 | 5.64 | 4.04-7.81 | 3.41 | 5.35 | 1.65 | 1.05 |
1+ | 888 | 6.83 | 5.10-9.09 | 2.92 | 5.64 | 2.34 | 1.21 |
All relatives with OC | |||||||
0 | 1395 | 6.09 | 4.72-7.84 | 3.26 | 4.53 | 1.87 | 1.34 |
1+ | 463 | 6.72 | 4.38-10.17 | 2.92 | 8.37 | 2.30 | 0.80 |
BRCA mutation status | |||||||
Test result positive | 110 | 16.29 | 9.70-26.07 | 3.77 | 33.8 | 4.32 | 0.48 |
Test result negative | 690 | 6.24 | 4.53-8.54 | 3.63 | 3.66 | 1.72 | 1.70 |
Untested | 1057 | 5 | 3.46-7.17 | 2.82 | 3.73 | 1.77 | 1.34 |
Race/Ethnicity | |||||||
Non-Hispanic White | 1270 | 7.09 | 5.65-8.85 | 3.52 | 6.15 | 2.01 | 1.15 |
Other | 587 | 2.6 | 1.18-5.63 | 2.43 | 4.06 | 1.07 | 0.64 |