Skip to main content

Table 2 Interaction between presence of estrogen receptor (ER) and p53 expression

From: Prognostic interaction between expression of p53 and estrogen receptor in patients with node-negative breast cancer: results from IBCSG Trials VIII and IX

  Hazard ratio 95% Confidence interval P-value
Disease-free survival models1    
p53 univariate (positive vs negative) 1.128 0.902, 1.410 0.3
ER univariate (present vs absent) 0.850 0.663, 1.090 0.2
Without interaction    
p53 1.044 0.815, 1.339 0.7
ER 0.866 0.660, 1.138 0.3
With interaction    
p53 0.606 0.390, 0.942 0.03
ER 0.606 0.431, 0.851 0.004
Inter p53/ER2 2.152 1.278, 3.623 0.004
With pathological variables3    
p53 0.575 0.368, 0.896 0.01
ER 0.747 0.517, 1.081 0.12
Inter p53/ER 1.968 1.156, 3.352 0.01
Grade 1 1.00 Reference 0.00094
Grade 2 1.463 1.018, 2.104  
Grade 3 1.988 1.362, 2.903  
Vascular invasion5 1.314 1.040, 1.661 0.02
With pathological and treatment variables    
p53 0.581 0.373, 0.906 0.02
ER 0.957 0.608, 1.507 0.85
Inter p53/ER 1.941 1.139, 3.307 0.01
Grade 1 1.00 Reference 0.0009
Grade 2 1.458 1.014, 2.097  
Grade 3 1.988 1.361, 2.904  
Vascular Invasion 1.305 1.033, 1.650 0.03
Tmt Endocrine only6 1.688 1.081, 2.636 0.02
Inter Tmt/ER7 0.595 0.360, 0.984 0.04
OS models    
p53 univariate 0.985 0.731, 1.326 0.9
ER univariate 0.667 0.493, 0.901 0.008
Without interaction    
p53 0.783 0.561, 1.092 0.15
ER 0.599 0.430, 0.836 0.003
With interaction    
p53 0.460 0.273, 0.777 0.004
ER 0.434 0.295, 0.638 <0.0001
Inter p53/ER 2.350 1.225, 4.507 0.01
With pathological variables    
p53 0.426 0.252, 0.719 0.001
ER 0.498 0.325, 0.763 0.001
Inter p53/ER 2.293 1.187, 4.433 0.01
T < = 1 cm 1.00 Reference 0.003
T >1 to 2 cm 1.858 0.932, 3.706  
T > 2 cm 2.682 1.340, 5.368  
Grade 1 1.00 Reference 0.11
Grade 2 1.578 0.957, 2.604  
Grade 3 1.759 1.041, 2.973  
Vascular invasion 1.309 0.971, 1.764 0.08
With pathological and treatment variables    
p53 0.427 0.253, 0.723 0.002
ER 0.604 0.355, 1.028 0.06
Inter p53/ER 2.280 1.179, 4.409 0.01
T < = 1 cm 1.00 Reference 0.002
T > 1 to 2cm 1.929 0.965, 3.856  
T > 2 cm 2.762 1.378, 5.536  
Grade 1 1.00 Reference 0.11
Grade 2 1.573 0.954, 2.594  
Grade 3 1.749 1.034, 2.957  
Vascular invasion 1.295 0.961, 1.745 0.09
Tmt endocrine only 1.574 0.931, 2.659 0.09
Inter Tmt/ER 0.666 0.363, 1.222 0.19
  1. 1Stratified by trial. 2Interaction term reflects cases with both expression of p53 and presence of ER. 3Tumor size was not significant and was dropped from the disease-free survival model. 4Peritumoral vascular invasion at central pathology review. 5P-values for multi-level variables (tumor size and grade) reflect overall significance. 6Treatment allocation endocrine only (goserelin in trial VIII, tamoxifen in trial IX) without chemotherapy. 7No interaction was seen between p53 status and the presence or absence of chemotherapy (data not shown). Inter, interaction (as detected by statistical analysis); Tmt, treatment allocation.