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Table 3 Logistic regression coefficients (ß), standard errors, and nominal significance levels of potentially predictive factors for BRCA1 or BRCA2 carriers

From: Triple-negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early-onset and familial breast cancer, but not in women with isolated late-onset breast cancer

Characteristic β Standard error P
Baseline -5.169 1.388 0.000
Proband breast cancer diagnosis ≤35 years 2.791 1.379 0.043
Proband breast cancer diagnosis 36-39 years 2.248 1.365 0.100
Proband breast cancer diagnosis 40-49 years 1.763 1.355 0.193
Proband breast cancer diagnosis 50-59 years 1.065 1.354 0.431
Proband bilateral breast cancer at any age 1.036 0.462 0.025
Proband ovarian cancer at any age 0.238 1.469 0.871
Proband triple-negative breast cancer at any age 1.323 0.331 0.000
For each relative with cancer:    
   First degree, breast cancer diagnosis ≤39 years 0.950 0.369 0.010
   First degree, breast cancer diagnosis 40-49 years 1.450 0.386 0.000
   First degree, breast cancer diagnosis 50-59 years 1.445 0.450 0.001
   First degree, breast cancer diagnosis 60+ years 0.207 0.646 0.749
   First degree, ovarian cancer at any age 2.556 0.769 0.001
   Second degree, breast cancer diagnosis at any age 0.359 0.272 0.187
   Second degree, ovarian cancer diagnosis at any age 1.861 0.832 0.025
  1. The multiple linear logistic regression analysis of the probability of breast cancer patients having a germline mutation in the BRCA1 or BRCA2 gene on the basis of age at diagnosis and family history of breast or ovarian cancers.