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Table 1 Characteristics of patients in Materials III, IV, V, and VI

From: Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes

   Material III prognosis (n= 233) Material IV prognosis (n= 291) Material V antiestrogen (n= 75) Material VI antiestrogen (n= 97)
   Number % Number % Number % Number %
Center Fox Chase 64 27 - - 19 25 - -
  Kaiser 79 34 - - 35 47 - -
  Univ of Miami 30 13 - - 11 15 - -
  Washington Univ 60 26 - - 10 13 - -
Race Asian 1 0.4 0 0 1 1.3 - -
  Black 16 7 3 1 6 8 - -
  White 216 93 287 99 67 89 - -
  Other 0 0 1 0.3 1 1.3 - -
Age (years) < 50 42 18 86 30 9 12 6 6
  ≥50 191 82 205 70 66 88 91 94
Size (cm) < 2 117 50 114 39 41 55 39 40
  ≥2 to < 5 107 46 133 46 34 45 43 44
  ≥5 9 4 33 11 0 0 11 11
  Missing 0 0 11 4 0 0 4 4
Grade 1 61 26 67 23 17 23 14 14
  2 104 45 137 47 45 60 47 48
  3 68 29 48 16 13 17 32 33
  Missing 0 0 39 13 0 0 4 4
ER status Negative 44 19 97 33 1 1.3 11 11
  Positive 186 80 163 56 72 96 80 82
  Missing 3 1.3 31 11 2 3 6 6
PR status Negative 65 28 103 35 9 12 - -
  Positive 122 52 151 52 56 75 - -
  Missing 46 20 37 13 10 13 - -
ER/PR status Negative 44 19 68 23 1 1.3 12 12
  Positive 178 76 192 66 72 96 83 86
  Missing 11 5 31 11 2 3 2 2
HER2 status Negative - - 217 75 - - 77 79
  Positive - - 33 11 - - 13 13
  Missing - - 41 14 - - 7 7
Nodal status Negative 233 100 291 100 73 100 42 43
  Positive 0 0 0 0 0 0 42 43
  Missing 0 0 0 0 0 0 13 13
Chemotherapy Untreated 233 100 - - 75 100 97 100
  Treated 0 0 - - 0 0 0 0
  Missing 0 0 - - 0 0 0 0
Hormone therapy Untreated 233 100 - - 0 0 0 0
  Treated 0 0 - - 75 100 97 100
Radiation therapy Untreated 187 80 - - 48 64 36 37
  Treated 46 20 - - 27 36 59 61
  Missing 0 0 - - 0 0 2 2
Stat5a status Low 30 13 200 69 9 12 24 25
  High 193 83 39 13 64 85 47 48
  Missing 10 4 52 18 2 3 26 27
CSS events Number 52 22 107 37 10 13 56 58
TTR events Number 56 24 - - 13 17 60 62
Evaluable subjects for multivariate Number 218 94 190 65 73 97 55 57
   Mean (Range) Mean (Range) Mean (Range) Mean (Range)
Stat5a score - 32 (0-90) 653 (175-2,099) 34.1 (0-80) 1,949 (727-4,626)
Date of diagnosis Year 1974-1990 1953-1980 1986-1996 1990-2000
Age at diagnosis Years 62.3 (31-88) 57.3 (24-86) 64.6 (43-88) 69.8 (38-89)
Tumor size cm 2.1 (0.6-7.5) 2.5 (0.4-11) 1.9 (0.5-4.5) 2.7 (0.4-11)
Follow-up Months 126 (3-326) 160 (1-425) 117 (10-195) 41 (4-143)
  1. ER, estrogen receptor; PR, progesterone receptor; SD, standard deviation.