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Table 1 Associations between CD44 genotypes and breast cancer risk.

From: CD44 rs13347 C>T polymorphism predicts breast cancer risk and prognosis in Chinese populations

 

Controls

(No, %)

Breast cancer patients

(No, %)

ORa(95% CI)

P-valueb

Discovery Set

N= 1,157

N= 1,049

  

rs13347 C>T

    

CC

654 (56.5)

451 (43.0)

1.00 (reference)

 

CT

430 (37.2)

484 (46.1)

1.69 (1.40 to 2.04)

< 10-5

TT

73 (6.3)

114 (10.9)

2.22 (1.59 to 3.10)

 

   CT+TT

503 (43.5)

598 (57.0)

1.77 (1.48 to 2.12)

 

C

1,738 (75.1)

1,386 (66.1)

1.00 (reference)

 

T

576 (24.9)

712 (33.9)

1.57 (1.37 to 1.80)

 

rs10836347 C>T

    

CC

995 (86)

906 (86.4)

1.00 (reference)

 

CT

156 (13.5)

139 (13.2)

0.98 (0.76 to 1.27)

 

TT

6 (0.5)

4 (0.4)

0.66 (0.18 to 2.43)

0.743

   CT+TT

162 (14)

143 (13.6)

0.97 (0.75 to 1.25)

 

C

2,146 (92.7)

1,951 (93.0)

1.00 (reference)

 

T

168 (7.3)

147 (7.0)

0.96 (0.75 to 1.22)

 

rs1425802 A>G

    

AA

353 (30.5)

316 (30.1)

1.00 (reference)

 

AG

563 (48.7)

513 (48.9)

1.04 (0.85 to 1.27)

 

GG

241 (20.8)

220 (21.0)

1.06 (0.82 to 1.36)

0.861

   AG+GG

804 (69.5)

733 (69.9)

1.04 (0.86 to 1.27)

 

A

1,269 (54.8)

1,145 (54.6)

1.00 (reference)

 

G

1,045 (45.2)

953 (45.4)

1.03 (0.91 to 1.17)

 

rs11821102 G>A

    

GG

997 (86.2)

912 (86.9)

1.00 (reference)

 

AG

151 (13)

125 (12.0)

0.85 (0.65 to 1.12)

 

AA

9 (0.8)

12 (1.1)

1.76 (0.70 to 4.470

0.802

   AG+AA

160 (13.8)

137 (13.1)

0.90 (0.69 to 1.16)

 

A

169 (7.3)

149 (7.1)

1.00 (reference)

 

G

2,145 (92.7)

1,949 (92.9)

0.95 (0.74 to 1.21)

 

rs713330 T>C

    

TT

950 (82.1)

865 (82.5)

1.00 (reference)

 

CT

194 (16.8)

172 (16.4)

0.97 (0.77 to 1.23)

 

CC

13 (1.1)

12 (1.1)

1.01 (0.43 to 2.38)

0.853

   CT+CC

207 (17.9)

184 (17.5)

0.98 (0.78 to 1.22)

 

T

2,094 (90.5)

1,902 (90.7)

1.00 (reference)

 

C

220 (9.5)

196 (9.3)

0.98 (0.80 to 1.21)

 

Validation Set

N = 835

N = 804

  

rs13347 C>T

    

CC

492 (58.9)

362 (45.0)

1.00 (reference)

 

CT

297 (35.6)

366 (45.5)

1.61 (1.31 to 1.98)

 

TT

46 (5.5)

76 (9.5)

2.25 (1.51 to 3.35)

< 10-5

   CT+TT

343 (41.1)

442 (55.0)

1.69 (1.39 to 2.07)

 

Pooled Analysis

N = 1,992

N = 1,853

  

rs13347 C>T

    

CC

1,146 (57.5)

813 (43.9)

1.00 (reference)

 

CT

727 (36.5)

850 (45.9)

1.64 (1.43 to 1.89)

 

TT

119 (6.0)

190 (10.2)

2.17 (1.68 to 2.80)

< 10-5

   CT+TT

1,886 (42.5)

1,040 (56.1)

1.72 (1.51 to 1.96)

 
  1. aData were calculated by unconditional logistic regression, adjusted for age, BMI and family history of breast cancer. bTests for trend of odds were two-sided and were based on likelihood ratio tests assuming a multiplicative model.