From: CD44 rs13347 C>T polymorphism predicts breast cancer risk and prognosis in Chinese populations
 | Controls (No, %) | Breast cancer patients (No, %) | ORa(95% CI) | P-valueb |
---|---|---|---|---|
Discovery Set | N= 1,157 | N= 1,049 | Â | Â |
rs13347 C>T | Â | Â | Â | Â |
CC | 654 (56.5) | 451 (43.0) | 1.00 (reference) | Â |
CT | 430 (37.2) | 484 (46.1) | 1.69 (1.40 to 2.04) | < 10-5 |
TT | 73 (6.3) | 114 (10.9) | 2.22 (1.59 to 3.10) | Â |
   CT+TT | 503 (43.5) | 598 (57.0) | 1.77 (1.48 to 2.12) |  |
C | 1,738 (75.1) | 1,386 (66.1) | 1.00 (reference) | Â |
T | 576 (24.9) | 712 (33.9) | 1.57 (1.37 to 1.80) | Â |
rs10836347 C>T | Â | Â | Â | Â |
CC | 995 (86) | 906 (86.4) | 1.00 (reference) | Â |
CT | 156 (13.5) | 139 (13.2) | 0.98 (0.76 to 1.27) | Â |
TT | 6 (0.5) | 4 (0.4) | 0.66 (0.18 to 2.43) | 0.743 |
   CT+TT | 162 (14) | 143 (13.6) | 0.97 (0.75 to 1.25) |  |
C | 2,146 (92.7) | 1,951 (93.0) | 1.00 (reference) | Â |
T | 168 (7.3) | 147 (7.0) | 0.96 (0.75 to 1.22) | Â |
rs1425802 A>G | Â | Â | Â | Â |
AA | 353 (30.5) | 316 (30.1) | 1.00 (reference) | Â |
AG | 563 (48.7) | 513 (48.9) | 1.04 (0.85 to 1.27) | Â |
GG | 241 (20.8) | 220 (21.0) | 1.06 (0.82 to 1.36) | 0.861 |
   AG+GG | 804 (69.5) | 733 (69.9) | 1.04 (0.86 to 1.27) |  |
A | 1,269 (54.8) | 1,145 (54.6) | 1.00 (reference) | Â |
G | 1,045 (45.2) | 953 (45.4) | 1.03 (0.91 to 1.17) | Â |
rs11821102 G>A | Â | Â | Â | Â |
GG | 997 (86.2) | 912 (86.9) | 1.00 (reference) | Â |
AG | 151 (13) | 125 (12.0) | 0.85 (0.65 to 1.12) | Â |
AA | 9 (0.8) | 12 (1.1) | 1.76 (0.70 to 4.470 | 0.802 |
   AG+AA | 160 (13.8) | 137 (13.1) | 0.90 (0.69 to 1.16) |  |
A | 169 (7.3) | 149 (7.1) | 1.00 (reference) | Â |
G | 2,145 (92.7) | 1,949 (92.9) | 0.95 (0.74 to 1.21) | Â |
rs713330 T>C | Â | Â | Â | Â |
TT | 950 (82.1) | 865 (82.5) | 1.00 (reference) | Â |
CT | 194 (16.8) | 172 (16.4) | 0.97 (0.77 to 1.23) | Â |
CC | 13 (1.1) | 12 (1.1) | 1.01 (0.43 to 2.38) | 0.853 |
   CT+CC | 207 (17.9) | 184 (17.5) | 0.98 (0.78 to 1.22) |  |
T | 2,094 (90.5) | 1,902 (90.7) | 1.00 (reference) | Â |
C | 220 (9.5) | 196 (9.3) | 0.98 (0.80 to 1.21) | Â |
Validation Set | N = 835 | N = 804 | Â | Â |
rs13347 C>T | Â | Â | Â | Â |
CC | 492 (58.9) | 362 (45.0) | 1.00 (reference) | Â |
CT | 297 (35.6) | 366 (45.5) | 1.61 (1.31 to 1.98) | Â |
TT | 46 (5.5) | 76 (9.5) | 2.25 (1.51 to 3.35) | < 10-5 |
   CT+TT | 343 (41.1) | 442 (55.0) | 1.69 (1.39 to 2.07) |  |
Pooled Analysis | N = 1,992 | N = 1,853 | Â | Â |
rs13347 C>T | Â | Â | Â | Â |
CC | 1,146 (57.5) | 813 (43.9) | 1.00 (reference) | Â |
CT | 727 (36.5) | 850 (45.9) | 1.64 (1.43 to 1.89) | Â |
TT | 119 (6.0) | 190 (10.2) | 2.17 (1.68 to 2.80) | < 10-5 |
   CT+TT | 1,886 (42.5) | 1,040 (56.1) | 1.72 (1.51 to 1.96) |  |