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Table 1 Associations between CD44 genotypes and breast cancer risk.

From: CD44 rs13347 C>T polymorphism predicts breast cancer risk and prognosis in Chinese populations

  Controls
(No, %)
Breast cancer patients
(No, %)
ORa(95% CI) P-valueb
Discovery Set N= 1,157 N= 1,049   
rs13347 C>T     
CC 654 (56.5) 451 (43.0) 1.00 (reference)  
CT 430 (37.2) 484 (46.1) 1.69 (1.40 to 2.04) < 10-5
TT 73 (6.3) 114 (10.9) 2.22 (1.59 to 3.10)  
   CT+TT 503 (43.5) 598 (57.0) 1.77 (1.48 to 2.12)  
C 1,738 (75.1) 1,386 (66.1) 1.00 (reference)  
T 576 (24.9) 712 (33.9) 1.57 (1.37 to 1.80)  
rs10836347 C>T     
CC 995 (86) 906 (86.4) 1.00 (reference)  
CT 156 (13.5) 139 (13.2) 0.98 (0.76 to 1.27)  
TT 6 (0.5) 4 (0.4) 0.66 (0.18 to 2.43) 0.743
   CT+TT 162 (14) 143 (13.6) 0.97 (0.75 to 1.25)  
C 2,146 (92.7) 1,951 (93.0) 1.00 (reference)  
T 168 (7.3) 147 (7.0) 0.96 (0.75 to 1.22)  
rs1425802 A>G     
AA 353 (30.5) 316 (30.1) 1.00 (reference)  
AG 563 (48.7) 513 (48.9) 1.04 (0.85 to 1.27)  
GG 241 (20.8) 220 (21.0) 1.06 (0.82 to 1.36) 0.861
   AG+GG 804 (69.5) 733 (69.9) 1.04 (0.86 to 1.27)  
A 1,269 (54.8) 1,145 (54.6) 1.00 (reference)  
G 1,045 (45.2) 953 (45.4) 1.03 (0.91 to 1.17)  
rs11821102 G>A     
GG 997 (86.2) 912 (86.9) 1.00 (reference)  
AG 151 (13) 125 (12.0) 0.85 (0.65 to 1.12)  
AA 9 (0.8) 12 (1.1) 1.76 (0.70 to 4.470 0.802
   AG+AA 160 (13.8) 137 (13.1) 0.90 (0.69 to 1.16)  
A 169 (7.3) 149 (7.1) 1.00 (reference)  
G 2,145 (92.7) 1,949 (92.9) 0.95 (0.74 to 1.21)  
rs713330 T>C     
TT 950 (82.1) 865 (82.5) 1.00 (reference)  
CT 194 (16.8) 172 (16.4) 0.97 (0.77 to 1.23)  
CC 13 (1.1) 12 (1.1) 1.01 (0.43 to 2.38) 0.853
   CT+CC 207 (17.9) 184 (17.5) 0.98 (0.78 to 1.22)  
T 2,094 (90.5) 1,902 (90.7) 1.00 (reference)  
C 220 (9.5) 196 (9.3) 0.98 (0.80 to 1.21)  
Validation Set N = 835 N = 804   
rs13347 C>T     
CC 492 (58.9) 362 (45.0) 1.00 (reference)  
CT 297 (35.6) 366 (45.5) 1.61 (1.31 to 1.98)  
TT 46 (5.5) 76 (9.5) 2.25 (1.51 to 3.35) < 10-5
   CT+TT 343 (41.1) 442 (55.0) 1.69 (1.39 to 2.07)  
Pooled Analysis N = 1,992 N = 1,853   
rs13347 C>T     
CC 1,146 (57.5) 813 (43.9) 1.00 (reference)  
CT 727 (36.5) 850 (45.9) 1.64 (1.43 to 1.89)  
TT 119 (6.0) 190 (10.2) 2.17 (1.68 to 2.80) < 10-5
   CT+TT 1,886 (42.5) 1,040 (56.1) 1.72 (1.51 to 1.96)  
  1. aData were calculated by unconditional logistic regression, adjusted for age, BMI and family history of breast cancer. bTests for trend of odds were two-sided and were based on likelihood ratio tests assuming a multiplicative model.