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Table 1 Characteristics of lobular carcinoma in situ and paired lesions

From: Clonal relatedness between lobular carcinoma in situ and synchronous malignant lesions

   

LCISb

Associated lesion

  
   

IHC profile

E-cadherin

Histology

Gradec

IHC profile

E-cadherin

  

Pair

Casea

Mastectomy

ER

PR

HER2

   

ER

PR

HER2

 

P value

Diagnosisd

LCIS and ILC

#32

Bilateral

+

+

-

NA

ILC classic

I

+

+

-

NA

0.07

I

 

#43

Left

+

+

-

NA

ILC classic

I

+

+

-

NA

0.99

I

 

#93

Left

+

+

-

-

ILC solid variant

II

+

+

-

-

0.004

E

 

#107

Bilateral

+

+

-

-

ILC classic

I

+

+

-

-

0.013

E

 

#114a

Bilateral

+

+

-

NA

ILC classic

I

+

+

-

NA

< 0.001

C

 

#114b

Bilateral

+

+

-

NA

ILC classic

I

+

+

-

NA

< 0.001

C

 

#121

Left

+

+

-

NA

ILC variant

II

+

+

-

NA

0.30

I

 

#122

Bilateral

+

+

-

-

ILC pleomorphic

III

+

+

-

-

< 0.001

C

 

#126

Right

+

+

-

NA

ILC classic

I

+

+

-

NA

0.009

E

LCIS and DCIS

#84

Bilateral

+

+

-

-

DCIS cribiform

Group 1

+

+

-

+

< 0.001

C

 

#95

Left

+

+

-

NA

DCIS micropapillary

Group 3

+

+

-

NA

< 0.001

C

 

#110

Bilateral

+

+

-

-

DCIS cribiform

Group 1

+

+

-

+

0.031

E

 

#120

Bilateral

+

+

-

-

DCIS papillary

Group 3

-

-

-

+

0.96

I

LCIS and IDC-LF

#76

Bilateral

+

+

-

-

ILC and IDC NST

II

+

+

-

ILC-negative, IDC-positive

< 0.001

C

 

#83

Left

+

+

-

-

ILC and IDC NST

I

+

+

-

-

0.12

I

LCIS and IDC

#95

Left

+

+

-

NA

IDC NST

III

+

+

-

NA

< 0.001

C

 

#110

Bilateral

+

+

-

-

IDC NST and micropapillary

II

+

+

-

+

0.004

E

  1. aSeventeen distinct comparisons of tumor pairs from 14 distinct patients. Case #114 involves samples from two distinct LCIS tumors (one in the upper outer quadrant and one in the lower outer quadrant) and one invasive lobular tumor. Case #76 involves samples from LCIS and the invasive lobular component of the mixed lesion. bAny nuclear staining was considered positive for estrogen receptor (ER) and progesterone receptor (PR). HER2 was graded according to the American Society of Clinical Oncology/College of American Pathologists guidelines [19]. All LCIS lesions were classic LCIS, except Case #122 that was classified as pleomorphic LCIS [18]. cInvasive cancers were graded according to the Scarff-Bloom and Richardson system modified by Elston and Ellis [16], and DCIS was graded according to the Van Nuys classification [17]. dC, clonal (P < 0.001); E, equivocal (0.001 <P < 0.05); I, independent (P > 0.05). DCIS, ductal carcinoma in situ; IDC, invasive ductal carcinoma; IDC-LF, invasive mammary carcinoma with mixed ductal and lobular features; IHC, immunohistochemistry; ILC, invasive lobular carcinoma; LCIS, lobular carcinoma in situ; NA, not available; NST, no special type.
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Breast Cancer Research

ISSN: 1465-542X

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