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Table 3 Risk of breast cancer associated with incomplete pregnancies and the TMAP score.

From: Variation in breast cancer risk associated with factors related to pregnancies according to truncating mutation location, in the French National BRCA1 and BRCA2 mutations carrier cohort (GENEPSO)

Reproductive factors One woman per family cohort: 39,666 person-years of follow-up BRCA1mutation carriers: 25,045 person-years of follow-up BRCA2mutation carriers: 14,621 person-years of follow-up
   Person-yearsa No. of casesa HR 95% CI Pvalue Person-yearsa No. of casesa HR 95% CI Pvalue Person-yearsa No. of casesa HR 95% CI Pvalue
Incomplete pregnancies b
  Never 33,455 219 1.00    21,291 135 1.00    12,164 84 1.00   
  Ever 5,995 155 1.28 0.98-1.67 0.07 3,673 103 1.30 0.95-1.76   2,322 52 1.07 0.64-1.78  
No. of incomplete pregnancies b
  0 33,455 219 1.00    21,291 135 1.00    12,164 84 1.00   
  1 4,208 103 1.25 0.93-1.69   2,544 70 1.27 0.89-1.82   1,664 33 0.96 0.53-1.73  
  2 1,320 32 1.07 0.69-1.66   841 21 1.08 0.65-1.79   479 11 1.01 0.46-2.24  
  ≥3 467 20 2.39 1.28-4.45 0.01 288 12 2.45 1.19-5.04 0.02 179 8 2.69 0.71-10.3  
  Trend    1.19 1.02-1.39 0.03    1.20 1.00-1.43 0.05    1.15 0.84-1.58  
Type of incomplete pregnancies b
  No incomplete pregnancies 33,384 219 1.00    21,220 135 1.00    12,164 84 1.00   
  Induced abortion only 2,909 71 1.29 0.93-1.81   1,859 50 1.35 0.92-1.99   1,050 21 1.02 0.53-1.96  
  Miscarriage only 2,494 65 1.19 0.83-1.72   1,407 41 1.14 0.73-1.78   1,087 24 1.05 0.54-2.04  
  Induced abortion and miscarriage 535 18 1.49 0.84-2.65   350 11 1.51 0.79-2.91   185 7 1.43 0.45-4.51  
No. of induced abortionsb
  0 35,968 286 1.00    22,666 177 1.00    13,302 109 1.00   
  1 2,833 66 1.15 0.83-1.60   1,805 47 1.22 0.84-1.78   1,028 19 0.87 0.45-1.68  
  2 497 16 1.44 0.74-2.78   322 10 1.59 0.75-3.40   175 6 1.47 0.44-4.88  
  ≥3 114 7 3.84 1.52-9.66 <10-3 82 4 3.31 1.13-9.71 0.03 32 3 7.85 1.74-35.5 0.01
  Trend    1.28 1.04-1.58 0.02    1.32 1.04-1.67 0.02    1.26 0.81-1.95  
No. of miscarriagesb
  0 36,419 293 1.00    23,121 186 1.00    13,298 107 1.00   
  1 2,273 64 1.21 0.85-1.72   1,321 41 1.20 0.79-1.82   952 23 1.01 0.50-2.02  
  2 508 12 0.98 0.48-1.99   301 6 0.69 0.27-1.81   207 6 1.54 0.64-3.67  
  ≥3 248 7 1.18 0.42-3.30   135 5 1.40 0.44-4.53   113 2 0.86 0.10-7.56  
  Trend    1.07 0.87-1.32     1.04 0.81-1.35     1.09 0.75-1.58  
Age at first induced abortionc
  <20 years 1,094 32 1.00    662 20 1.00    432 12 1.00   
  ≥ 20 years 2,350 57 0.50 0.28-0.90 0.02 1,547 41 0.53 0.27-1.02 0.06 803 16 0.40 0.10-1.53  
  No induced abortion 35,968 286 0.74 0.31-1.78   22,666 177 0.70 0.27-1.84   13,302 109 1.10 0.12-10.5  
Age at first miscarriagec
  <20 years 220 5 1.00    202 5 1.00    18 0    
  ≥ 20 2,809 78 1.04 0.25-4.28   1,555 47 0.87 0.20-3.73   1,254 31    
  No miscarriage 36,419 293 0.81 0.17-3.99   23,121 186 0.69 0.12-3.93   13,298 107    
Induced abortion relative to the first full-term pregnancyb
  No induced abortion 35,964 284 1.00    22,663 175 1.00    13,301 109 1.00   
  Before first full-term pregnancy 1,835 49 1.77 1.19-2.63 0.01 1,223 33 1.77 1.13-2.77 0.01 612 16 1.88 0.86-4.12  
  After first full-term pregnancy 1,613 42 0.97 0.65-1.45   989 30 1.14 0.72-1.79   624 12 0.55 0.26-1.18  
Miscarriage relative to the first full-term pregnancyb
1.00
  No miscarriage 36,414 291     23,118 186 1.00    13,296 105 1.00   
  Before first full-term pregnancy 1,138 29 1.07 0.65-1.77   729 20 1.01 0.55-1.84   409 9 0.89 0.36-2.16  
  After first full-term pregnancy 1,896 56 1.05 0.73-1.51   1,031 32 1.02 0.65-1.60   865 24 1.09 0.57-2.08  
Type and length of incomplete pregnanciesb
  No abortion 33,384 219 1.00    21,220 135 1.00    12,164 84 1.00   
  Induced abortion only 2,909 71 1.30 0.93-1.82   1,859 50 1.36 0.92-2.00   1,050 21 1.01 0.52-1.95  
  Miscarriage with length ≤3 months 2,492 74 1.35 0.95-1.93 0.09 1,461 45 1.27 0.84-1.94   1,031 29 1.35 0.69-2.67  
  Miscarriage with length >3 months 436 8 0.93 0.41-2.12   253 7 1.17 0.47-2.95   183 1 0.14 0.02-1.24 0.08
TMAP score (not including never pregnant women)d
  ]0-0.35] 7,545 141 1.00    4,564 85 1.00    2,981 56 1.00   
  ]0.35-0.40] 3,416 88 1.05 0.75-1.48   2,154 59 0.99 0.66-1.48   1,262 29 1.09 0.60-1.98  
  ]0.40-0.45] 1,735 51 1.23 0.81-1.86   1,034 30 1.12 0.67-1.87   701 21 1.33 0.68-2.59  
  ]0.45-0.50] 589 17 1.53 0.80-2.93   433 14 1.41 0.68-2.92   156 3 1.70 0.37-7.71  
  ]0.5-1.00] 1,186 22 1.97 1.19-3.29 0.01 722 12 1.91 1.07-3.42 0.03 464 10 2.04 0.79-5.24  
  Trend    1.16 1.03-1.30 0.02    1.14 0.99-1.32 0.07    1.17 0.95-1.44  
  1. a Not including missing data. bAdjusted for parity (0, 1, 2, ≥3), menopausal status (yes, no), oral contraceptives (never, ever), and gene mutated (BRCA1, BRCA2). cAdjusted for parity (0,1 2, ≥3), no. of incomplete pregnancies (0, 1, 2, ≥3), menopausal status (yes, no), oral contraceptives (never, ever), and gene mutated (BRCA1, BRCA2). dAdjusted for menopausal status (yes, no), oral contraceptives (never, ever), and gene mutated (BRCA1, BRCA2). HR, hazard ratio; CI, confidence interval.