Dual-energy contrast-enhanced digital mammography: initial clinical results of a multireader, multicase study

Breast Cancer Research

Table 4 Per-lesion sensitivity to malignant lesions and false-positive marks per case using BI-RADS score of at least 4 to define a positive mark

Reader	MX ± US	MX ± US ± CEDM	Difference	Pvalue
Sensitivity
1	0.702 ± 0.050	0.762 ± 0.047	0.060	0.13
2	0.738 ± 0.048	0.81 ± 0.043	0.071	0.08
3	0.738 ± 0.048	0.845 ± 0.040	0.107	0.01
4	0.762 ± 0.047	0.821 ± 0.042	0.060	0.07
5	0.702 ± 0.05	0.738 ± 0.048	0.036	0.50
6	0.631 ± 0.053	0.690 ± 0.051	0.060	0.18
Overall	0.712 ± 0.043	0.778 ± 0.040	0.065 ± 0.024	0.006
95% CI	0.628 to 0.797	0.697 to 0.858	0.019 to 0.112
False-positive marks per case (cases without malignant lesions)
1	0.478 ± 0.056	0.652 ± 0.064	0.174	0.034
2	0.565 ± 0.056	0.435 ± 0.052	-0.130	0.128
3	0.652 ± 0.058	0.674 ± 0.067	0.022	0.745
4	1.043 ± 0.06	0.978 ± 0.065	-0.065	0.545
5	0.717 ± 0.052	0.609 ± 0.051	-0.108	0.134
6	0.478 ± 0.056	0.478 ± 0.063	0.000	1.000
Overall	0.656 ± 0.092	0.638 ± 0.089	-0.018 ± 0.050	0.726
95% CI	0.443 to 0.869	0.434 to 0.842	-0.135 to 0.099

BI-RADS, Breast Imaging, Reporting and Data System; CEDM, contrast-enhanced digital mammography; CI, confidence interval; MX, mammography; US, ultrasonography.

ISSN: 1465-542X