Endometrial cancer survival after breast cancer in relation to tamoxifen treatment: Pooled results from three countries

Jones, Michael E; van Leeuwen, Flora E; Hoogendoorn, Wilhelmina E; Mourits, Marian JE; Hollema, Harry; van Boven, Hester; Press, Michael F; Bernstein, Leslie; Swerdlow, Anthony J

doi:10.1186/bcr3206

Table 1 Characteristics of patients with endometrial cancer after breast cancer, by study

From: Endometrial cancer survival after breast cancer in relation to tamoxifen treatment: Pooled results from three countries

	Study						Total
	NL		UK		US
	N	%	N	%	n	%	N	%
Age at diagnosis of breast cancer (years)
< 45	40	5.2	36	4.6	6	1.9	82	4.4
45 to 54	147	19.2	170	21.6	35	10.8	352	18.8
55 to 64	231	30.2	256	32.6	108	33.3	595	31.7
65 to 74	246	32.2	224	28.5	119	36.7	589	31.4
75 to 84	91	11.9	92	11.7	47	14.5	230	12.3
85 and over	10	1.3	8	1.0	9	2.8	27	1.4
Age at diagnosis of endometrial cancer (years)
< 55	72	9.4	94	12.0	24	7.4	190	10.1
55 to 64	183	23.9	215	27.4	71	21.9	469	25.0
65 to 74	277	36.2	238	30.3	138	42.6	653	34.8
75 to 84	184	24.1	187	23.8	74	22.8	445	23.7
85 and over	49	6.4	52	6.6	17	5.2	118	6.3
Year of diagnosis of breast cancer
1972 to 1979	37	4.8	60	7.6	33	10.2	130	6.9
1980 to 1984	98	12.8	196	24.9	122	37.7	416	22.2
1985 to 1989	163	21.3	376	47.8	147	45.4	686	36.6
1990 to 1995	238	31.1	150	19.1	22	6.8	410	21.9
1995 to 1999	152	19.9	4	0.5	0	0.0	156	8.3
2000 to 2005	77	10.1	0	0.0	0	0.0	77	4.1
Year of diagnosis of endometrial cancer
1978 to 1984	16	2.1	0	0.0	38	11.7	54	2.9
1985 to 1989	63	8.2	112	14.3	143	44.1	318	17.0
1990 to 1994	141	18.4	501	63.7	143	44.1	785	41.9
1995 to 1999	257	33.6	173	22.0	0	0.0	430	22.9
2000 to 2006	288	37.6	0	0.0	0	0.0	288	15.4
Extent of disease (breast cancer)^a
Localized	362	47.3	317	40.3	198	61.1	877	46.8
Regional extension	295	38.6	150	19.1	121	37.4	566	30.2
Metastatic disease	15	2.0	4	0.5	5	1.5	24	1.3
Unknown	93	12.2	315	40.1	0	0.0	408	21.8
Interval between breast and endometrial cancers (years)
< 1	35	4.6	47	6.0	34	10.5	116	6.2
1 to < 3	192	25.1	135	17.2	126	38.9	453	24.2
3 to < 5	150	19.6	134	17.1	73	22.5	357	19.0
5 to < 10	231	30.2	326	41.5	78	24.1	635	33.9
10 to 29	157	20.5	144	18.3	13	4.0	314	16.8
Morphological type of endometrial cancer
Endometrioid adenocarcinoma^b	636	83.1	666	84.7	278	85.8	1580	84.3
Serous or clear cell^c	64	8.4	24	3.1	20	6.2	108	5.8
Carcinosarcoma^d	37	4.8	56	7.1	15	4.6	108	5.8
Sarcoma^e	26	3.4	19	2.4	9	2.8	54	2.9
Not known	2	0.3	21	2.7	2	0.6	25	1.3
All patients	765	100.0	786	100.0	324	100.0	1875	100.0

^aLocalized: no lymph node involvement; Regional extension: spread to lymph nodes; ^bEndometrial adenocarcinoma, mixed cell adenocarcinoma, papillary endometrial adenocarcinoma; ^cSerous adenocarcinoma, clear cell adenocarcinoma; ^dCarcinosarcoma, Mullerian mesodermal mixed tumors; ^eSarcoma, endometrial stromal adenocarcinoma, leiomyosarcoma.

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ISSN: 1465-542X

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