Figure 5
Effects of plakoglobin expression on tumor growth in vivo. Ten Balb/c nude mice per group were inoculated with 1 × 105 MCF7 control or MCF7 3C-3 cells (A) or 1 × 105 T47D control or T47D 2A-4 (B) into the fifth and tenth mammary fat pads. Tumors were measured twice per week, and all animals were killed 32 (MCF7) or 34 (T47D) days after tumor implantation. Data show mean ± SEM tumor volume over time. (C) Plakoglobin expression in excised MCF7 control and 3C-3 tumors. (D) Plakoglobin expression in excised T47D control and 2A-4 tumors. PCR data are shown as a percentage of GAPDH. (*P < 0.05, by one-way ANOVA, followed by the Dunnett two-sided multiple comparison test).