Figure 2

JMJD6 expression and prognosis in intrinsic subtypes of breast cancer. Box plots of JMJD6 expression demonstrate (A) higher JMJD6 probeset intensity (log2) in ER^- tumors compared with ER⁺ tumors, with P < 0.001 by Mann-Whitney Rank Sum test; and (B) highest JMJD6 probeset intensity (log2) in claudin-low and basal subtypes, followed by HER2-enriched and LumB subtypes, and lowest in LumA subtypes. The Dunn method was used to perform pairwise multiple comparison among the subtypes. *P < 0.05 between a pair of subtypes. Dots of boxplots (A, B) represent outliers in the 90^th and 10^th percentiles. Kaplan-Meier survival curves based on below-median (low) and above-median (high) JMJD6 expression are shown for (C) ER⁺ patients, (D) patients of LumA subtype, (E) patients of LumB subtype, and (F) ER⁺, tamoxifen-treated patients. The numbers in the parentheses equal patient numbers in each group, and the log rank P value is indicated at the bottom left of each figure.