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Figure 3 | Breast Cancer Research

Figure 3

From: Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer

Figure 3

Prognosis of up-regulated HSP90. (A) Correlation between HSP90AA1, HSP90AB1 and HSF1 copy number aberrations and HSP90AA1 and HSP90AB1 expression. Differences between up-regulated HSP90 and others were assessed using the exact Mann-Whitney U test. Boxes represent the 25% to 75% quartiles, lines in the boxes represent the median level, whiskers represent the non-outlier range, and circles represent the outliers. (B) Distribution of HSP90AA1, HSP90AB1 and HSF1 copy number aberrations across 481 TCGA samples. (C) Prognosis of high-level expression of HSP90AA1 or HSP90AB1, and up-regulated HSP90. Kaplan-Meier estimates of disease specific survival (event of death from breast cancer) in 395 breast cancer patients (number of events, n = 83) and over-all survival in 1,027 breast cancer patients (number of events, n = 248). P values were calculated using log-rank Mantel-cox test. Tick marks indicate patients whose data were censored by the time of last follow-up.

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Breast Cancer Research

ISSN: 1465-542X

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