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Table 4 Association of candidate single-nucleotide polymorphism loci and risk of breast cancer by estrogen receptor status in the Nurses' Health Study and Women's Genome Health Study

From: Reproductive aging-associated common genetic variants and the risk of breast cancer

SNP

All cases

ER+

ER-

ER+/ER-

 

OR (95% CI)a

Pvalueb

OR (95% CI)a

Pvalueb

OR (95% CI)a

Pvalueb

Pvalue for heterogeneityc

Cases/Controlsd

2,087/23,319

1,716/23,319

371/23,319

 

Age at menarche

       

rs1079866

1.22 (1.10-1.35)

2.0 × 10-4

1.26 (1.12-1.41)

7.3 × 10-5

1.11 (0.89-1.38)

0.34

0.31

rs7821178

1.12 (1.04-1.20)

3.3 × 10-3

1.10 (1.01-1.19)

0.025

1.14 (0.98-1.34)

0.10

0.66

rs17188434

1.15 (1.00-1.33)

0.048

1.08 (0.92-1.26)

0.34

1.51 (1.15-1.98)

2.7 × 10-3

0.035

rs13187289

0.92 (0.84-1.00)

0.055

0.90 (0.82-0.99)

0.026

1.05 (0.87-1.28)

0.60

0.15

rs10980926

0.93 (0.87-1.00)

0.067

0.94 (0.87-1.02)

0.14

0.90 (0.77-1.05)

0.17

0.58

rs7642134

1.06 (0.99-1.14)

0.12

1.07 (0.99-1.16)

0.089

1.09 (0.93-1.27)

0.28

0.86

rs10423674

1.05 (0.97-1.13)

0.22

1.06 (0.97-1.15)

0.19

0.95 (0.81-1.11)

0.50

0.23

rs6589964

0.95 (0.89-1.03)

0.22

0.94 (0.87-1.02)

0.13

1.00 (0.85-1.17)

0.98

0.51

rs1398217

1.04 (0.97-1.12)

0.25

1.02 (0.95-1.10)

0.57

1.11 (0.95-1.29)

0.19

0.36

rs1659127

1.03 (0.96-1.12)

0.41

1.00 (0.92-1.09)

0.98

1.09 (0.92-1.29)

0.32

0.38

rs12617311

0.97 (0.89-1.05)

0.44

1.00 (0.91-1.09)

0.93

0.94 (0.79-1.12)

0.48

0.56

rs17268785

1.04 (0.94-1.14)

0.48

1.07 (0.96-1.19)

0.22

0.83 (0.68-1.00)

0.055

0.023

rs2090409

0.97 (0.90-1.05)

0.50

0.96 (0.89-1.05)

0.38

0.98 (0.84-1.15)

0.82

0.85

rs10899489

1.03 (0.93-1.14)

0.52

1.02 (0.92-1.14)

0.67

0.98 (0.79-1.21)

0.86

0.72

rs6438424

0.98 (0.91-1.05)

0.55

0.99 (0.92-1.07)

0.79

0.98 (0.84-1.14)

0.76

0.88

rs2002675

1.02 (0.95-1.10)

0.55

1.04 (0.96-1.12)

0.35

0.94 (0.81-1.10)

0.45

0.27

rs466639

1.02 (0.92-1.14)

0.73

1.05 (0.94-1.18)

0.39

0.94 (0.74-1.20)

0.62

0.41

rs7759938

1.01 (0.93-1.09)

0.84

1.02 (0.94-1.11)

0.63

1.00 (0.84-1.17)

0.96

0.80

rs9635759

1.01 (0.93-1.09)

0.88

1.00 (0.92-1.09)

0.98

1.03 (0.87-1.22)

0.72

0.74

Age at natural menopause

       

rs2517388

1.14 (1.03-1.25)

0.010

1.11 (1.00-1.24)

0.046

1.32 (1.09-1.61)

4.7 × 10-3

0.12

rs2303369

0.93 (0.86-1.00)

0.036

0.93 (0.86-1.01)

0.076

0.94 (0.80-1.09)

0.42

0.94

rs12461110

0.93 (0.86-1.00)

0.042

0.91 (0.84-0.99)

0.022

0.95 (0.81-1.11)

0.50

0.66

rs4886238

1.06 (0.99-1.14)

0.11

1.06 (0.98-1.15)

0.14

1.03 (0.88-1.21)

0.68

0.76

rs16991615

1.09 (0.94-1.26)

0.23

1.13 (0.97-1.32)

0.12

0.99 (0.71-1.37)

0.94

0.46

rs2277339

1.07 (0.95-1.20)

0.28

1.09 (0.96-1.24)

0.21

1.02 (0.80-1.31)

0.85

0.68

rs12294104

1.04 (0.95-1.14)

0.41

1.06 (0.96-1.17)

0.28

0.98 (0.80-1.21)

0.89

0.54

rs4246511

1.03 (0.95-1.12)

0.42

1.05 (0.96-1.15)

0.29

0.95 (0.79-1.14)

0.59

0.34

rs10852344

1.03 (0.96-1.10)

0.42

1.04 (0.96-1.12)

0.31

0.99 (0.85-1.15)

0.88

0.56

rs2153157

1.03 (0.96-1.10)

0.45

1.04 (0.96-1.12)

0.32

1.00 (0.87-1.17)

0.95

0.69

rs4693089

0.98 (0.91-1.05)

0.54

0.98 (0.91-1.07)

0.68

0.91 (0.77-1.06)

0.23

0.37

rs10183486

0.98 (0.91-1.06)

0.67

0.98 (0.91-1.06)

0.64

0.91 (0.78-1.06)

0.23

0.39

rs2307449

0.99 (0.92-1.06)

0.72

0.96 (0.89-1.04)

0.36

1.06 (0.91-1.24)

0.47

0.29

rs1635501

0.99 (0.91-1.07)

0.76

0.99 (0.90-1.08)

0.80

0.99 (0.83-1.19)

0.94

0.97

rs11668344

1.01 (0.94-1.08)

0.81

1.00 (0.92-1.08)

0.92

1.05 (0.89-1.22)

0.58

0.59

rs1046089

0.99 (0.92-1.07)

0.89

1.02 (0.94-1.10)

0.67

0.90 (0.77-1.05)

0.19

0.17

rs365132

1.00 (0.93-1.07)

0.97

1.00 (0.93-1.08)

1.00

1.00 (0.86-1.16)

0.95

0.96

Breast cancer

       

rs11249433

1.20 (1.12-1.29)

4.8 × 10-7

1.23 (1.14-1.33)

6.9 × 10-8

1.06 (0.91-1.23)

0.45

0.081

rs3803662

1.20 (1.12-1.30)

1.8 × 10-6

1.26 (1.16-1.37)

4.2 × 10-8

0.98 (0.82-1.16)

0.78

0.008

rs2981582

1.18 (1.10-1.27)

8.2 × 10-6

1.19 (1.10-1.29)

1.1 × 10-5

1.01 (0.87-1.19)

0.86

0.071

rs13281615

1.16 (1.08-1.24)

3.9 × 10-5

1.16 (1.07-1.25)

2.1 × 10-4

1.15 (0.99-1.33)

0.074

0.94

rs13387042

1.15 (1.07-1.23)

8.4 × 10-5

1.17 (1.08-1.26)

6.3 × 10-5

1.01 (0.87-1.18)

0.85

0.10

rs7716600

1.17 (1.08-1.27)

1.6 × 10-4

1.18 (1.08-1.29)

2.9 × 10-4

1.21 (1.02-1.44)

0.029

0.77

rs889312

1.10 (1.02-1.19)

0.012

1.10 (1.01-1.20)

0.026

1.18 (1.00-1.39)

0.046

0.45

rs999737

1.09 (1.00-1.18)

0.049

1.10 (1.01-1.21)

0.031

0.99 (0.84-1.18)

0.95

0.29

rs1045485

1.09 (0.98-1.20)

0.12

1.06 (0.95-1.19)

0.28

1.20 (0.95-1.52)

0.12

0.35

rs3817198

1.03 (0.96-1.12)

0.38

1.06 (0.98-1.15)

0.16

0.88 (0.74-1.04)

0.13

0.047

  1. aPer-risk-allele odds ratio (OR) of breast cancer; bP value from meta-analysis of the Nurses' Health Study (NHS) and the Women's Genome Health Study (WGHS) with additive genetic coding after adjustment for age and potential population stratification; cP value from heterogeneity test across estrogen receptor-positive (ER+) and ER- tumors; dtotal number of cases or controls in the NHS and the WGHS. CI, confidence interval; SNP, single-nucleotide polymorphism.
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Breast Cancer Research

ISSN: 1465-542X

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