Figure 8

Proposed role of PC-PLC in piloting cell signaling effects on breast cancer cell proliferation and differentiation. Metabolites/second messengers: CDP-Cho, cytidine 5'-diphosphocholine; Cho, free choline; DAG, diacylglycerol; IP3, inositol (1,4,5)-trisphosphate; PA, phosphatidate; PCho, phosphocholine; PIP2, phosphatidylinositol (4,5)-bisphosphate; PIP3, phosphatidylinositol (3,4,5)-trisphosphate; PtdCho, phosphatidylcholine. Inhibitors: R, rapamycin and its analogs. Enzymes/protein kinases: AKT/PKB, AKT/protein kinase B; CCT, phosphocholine-cytidylyl transferase; CDP-Cho, cytidine 5'-diphosphocholine; ChoK, choline kinase; DAGK, diacylglycerol kinase; MAPK, mitogen-activated protein kinase; mTOR, mammalian target of rapamycin; PAP, phosphatidate phosphohydrolase; PC-PLC, phosphatidylcholine-specific phospholipase C; PCT, phosphocholine diacylglycerol transferase; P-ERK, phosphorylated extracellular signal-regulated kinase; PI3K, phosphoinositide 3-kinase; PI-PLC, phosphoinositide-specific phospholipase C; PKC, protein kinase C; PLD, phospholipase D; PTEN, phosphatase and tensin homolog. Black arrows indicate chemical reactions, dotted green arrows represent stimulation or other link, blue dotted arrows represent molecular transport or transfer to a different site, and solid gray arrows point to biological effects.