Figure 7From: Inhibition of phosphatidylcholine-specific phospholipase C results in loss of mesenchymal traits in metastatic breast cancer cellsSchematic representation of major links between pathways of biosynthesis and catabolism of phosphatidylcholine (PtdCho) and sphingomyelin (SM) and their relationships with membrane synthesis and apoptosis. The dose-dependent effects of D609 on phospholipase C (PLC) and sphingomyelin synthase (SMS) inhibition and on stimulation of ceramide synthase are described in the Discussion section. CCT, phosphocholine-cytidylyl transferase; CDP-Cho, cytidine 5'-diphosphocholine; Cho, free choline; ChoK, choline kinase; DAG, diacylglycerol; PCho, phosphocholine; SMase, sphingomyelinase.Back to article page