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Table 3 Biologic and cellular functions of miR-215, miR-299-5p, miR-411, and miR-452

From: Expression profiling of cancerous and normal breast tissues identifies microRNAs that are differentially expressed in serum from patients with (metastatic) breast cancer and healthy volunteers

miRNA Network ID Score Number of genes Top associated functions
miR-215 1 37 28 Tissue morphology, cell death, drug metabolism
  2 20 19 Developmental disorder, gene expression, genetic disorder
  3 20 19 Cellular movement, immune cell trafficking, skeletal and muscular system development and function
  4 14 15 RNA damage and repair, cell death, molecular transport
  5 13 14 Genetic disorder, cellular assembly and organization, cellular function and maintenance
miR-299-5p 1 35 29 Cell-to-cell signaling and interaction, cellular growth and proliferation, tumor morphology
  2 24 23 Gene expression, cellular movement, lipid metabolism
  3 13 16 Cellular assembly and organization, DNA replication, recombination, and repair, gene expression
  4 13 16 Cell morphology, cellular development, protein synthesis
  5 11 14 Cell death, renal necrosis/cell death, cellular compromise
miR-411 1 33 26 Cell death, cell-to-cell signaling and interaction, cell-mediated immune response
  2 27 23 Cardiovascular system development and function, organ development, organismal development
  3 17 17 Gene expression, protein synthesis, antimicrobial response
  4 14 15 Cell death, cellular growth and proliferation, cellular assembly and organization
  5 11 13 Inflammatory response, dermatologic diseases and conditions, inflammatory disease
miR-452 1 31 32 Gene expression, cellular movement, cell death
  2 27 30 Cell-to-cell signaling and interaction, connective tissue development and function, cell morphology
  3 25 29 Cellular growth and proliferation, inflammatory response, cell death
  4 25 29 Cellular development, gene expression, nervous system development and function
  5 25 29 Cellular growth and proliferation, cardiovascular disease, tissue morphology