Table 3 Biologic and cellular functions of miR-215, miR-299-5p, miR-411, and miR-452

miR-215

1

37

28

Tissue morphology, cell death, drug metabolism

2

20

19

Developmental disorder, gene expression, genetic disorder

3

20

19

Cellular movement, immune cell trafficking, skeletal and muscular system development and function

4

14

15

RNA damage and repair, cell death, molecular transport

5

13

14

Genetic disorder, cellular assembly and organization, cellular function and maintenance

miR-299-5p

1

35

29

Cell-to-cell signaling and interaction, cellular growth and proliferation, tumor morphology

2

24

23

Gene expression, cellular movement, lipid metabolism

3

13

16

Cellular assembly and organization, DNA replication, recombination, and repair, gene expression

4

13

16

Cell morphology, cellular development, protein synthesis

5

11

14

Cell death, renal necrosis/cell death, cellular compromise

miR-411

1

33

26

Cell death, cell-to-cell signaling and interaction, cell-mediated immune response

2

27

23

Cardiovascular system development and function, organ development, organismal development

3

17

17

Gene expression, protein synthesis, antimicrobial response

4

14

15

Cell death, cellular growth and proliferation, cellular assembly and organization

5

11

13

Inflammatory response, dermatologic diseases and conditions, inflammatory disease

miR-452

1

31

32

Gene expression, cellular movement, cell death

2

27

30

Cell-to-cell signaling and interaction, connective tissue development and function, cell morphology

3

25

29

Cellular growth and proliferation, inflammatory response, cell death

4

25

29

Cellular development, gene expression, nervous system development and function

5

25

29

Cellular growth and proliferation, cardiovascular disease, tissue morphology