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Table 5 Associations with estrogen receptor-positive and estrogen receptor-negative breast cancer risk for BRCA1 and BRCA2 carriers.

From: Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2mutation carriers

      ER-positive ER-negative  
  Unaffected
N
ER-positive N ER-negative N ER status unknown N HR 95% CI P-value HR 95% CI P-value P-dif
CDK2NA/B - rs1011970           
BRCA1 4,893 559 1,888 2,841 0.95 0.81 to 1.12 0.56 1.03 0.95 to 1.11 0.47 0.41
BRCA2 2,928 1,372 424 1,649 1.10 1.00 to 1.22 0.05 1.15 0.96 to 1.37 0.12 0.70
ZNF365 - rs10995190           
BRCA1 4,895 559 1,887 2,843 0.88 0.74 to 1.04 0.14 1.01 0.94 to 1.10 0.75 0.16
BRCA2 2,927 1,370 406 1,648 0.89 0.80 to 1.00 0.043 0.87 0.71 to 1.07 0.19 0.84
ZMIZ1 - rs704010           
BRCA1 4,842 548 1,846 2,811 1.12 1.00 to 1.26 0.046 1.00 0.94 to 1.06 0.91 0.08
BRCA2 2,887 1,347 401 1,636 1.01 0.93 to 1.09 0.91 1.00 0.87 to 1.14 0.95 0.91
10p15 - rs2380205           
BRCA1 4,465 540 1,812 2,513 0.90 0.80 to 1.01 0.08 1.02 0.96 to 1.09 0.46 0.06
BRCA2 2,701 1,341 396 1,543 1.02 0.95 to 1.10 0.60 0.94 0.82 to 1.08 0.39 0.31
11q13 - rs614367           
BRCA1 4,879 557 1,886 2,832 1.09 0.93 to 1.29 0.30 1.04 0.96 to 1.12 0.40 0.59
BRCA2 2,921 1,365 405 1,639 1.06 0.96 to 1.17 0.26 0.84 0.69 to 1.04 0.10 0.05
12q24 - rs1292011           
BRCA1 3,429 308 1,043 2,031 0.87 0.74 to 1.02 0.09 1.05 0.98 to 1.13 0.12 0.046
BRCA2 2,065 813 239 1,170 0.95 0.86 to 1.04 0.28 0.98 0.82 to 1.16 0.78 0.79
PTHLH - rs10771399           
BRCA1 4,889 557 1,887 2,842 0.94 0.78 to 1.13 0.52 0.81 0.74 to 0.90 3.8 × 10 -5 0.20
BRCA2 2,926 1,366 406 1,648 0.97 0.86 to 1.10 0.68 0.78 0.62 to 1.00 0.049 0.12
9q31.2 - rs865686           
BRCA1 4,892 559 1,888 2,836 0.92 0.81 to 1.03 0.15 1.01 0.95 to 1.08 0.68 0.16
BRCA2 2,924 1,370 405 1,645 0.91 0.84 to 0.99 0.028 1.07 0.92 to 1.25 0.40 0.08
  1. ER, estrogen receptor; HR, hazard ratio