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Table 5 Associations with estrogen receptor-positive and estrogen receptor-negative breast cancer risk for BRCA1 and BRCA2 carriers.

From: Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2mutation carriers

     

ER-positive

ER-negative

 
 

Unaffected

N

ER-positive N

ER-negative N

ER status unknown N

HR

95% CI

P-value

HR

95% CI

P-value

P-dif

CDK2NA/B - rs1011970

          

BRCA1

4,893

559

1,888

2,841

0.95

0.81 to 1.12

0.56

1.03

0.95 to 1.11

0.47

0.41

BRCA2

2,928

1,372

424

1,649

1.10

1.00 to 1.22

0.05

1.15

0.96 to 1.37

0.12

0.70

ZNF365 - rs10995190

          

BRCA1

4,895

559

1,887

2,843

0.88

0.74 to 1.04

0.14

1.01

0.94 to 1.10

0.75

0.16

BRCA2

2,927

1,370

406

1,648

0.89

0.80 to 1.00

0.043

0.87

0.71 to 1.07

0.19

0.84

ZMIZ1 - rs704010

          

BRCA1

4,842

548

1,846

2,811

1.12

1.00 to 1.26

0.046

1.00

0.94 to 1.06

0.91

0.08

BRCA2

2,887

1,347

401

1,636

1.01

0.93 to 1.09

0.91

1.00

0.87 to 1.14

0.95

0.91

10p15 - rs2380205

          

BRCA1

4,465

540

1,812

2,513

0.90

0.80 to 1.01

0.08

1.02

0.96 to 1.09

0.46

0.06

BRCA2

2,701

1,341

396

1,543

1.02

0.95 to 1.10

0.60

0.94

0.82 to 1.08

0.39

0.31

11q13 - rs614367

          

BRCA1

4,879

557

1,886

2,832

1.09

0.93 to 1.29

0.30

1.04

0.96 to 1.12

0.40

0.59

BRCA2

2,921

1,365

405

1,639

1.06

0.96 to 1.17

0.26

0.84

0.69 to 1.04

0.10

0.05

12q24 - rs1292011

          

BRCA1

3,429

308

1,043

2,031

0.87

0.74 to 1.02

0.09

1.05

0.98 to 1.13

0.12

0.046

BRCA2

2,065

813

239

1,170

0.95

0.86 to 1.04

0.28

0.98

0.82 to 1.16

0.78

0.79

PTHLH - rs10771399

          

BRCA1

4,889

557

1,887

2,842

0.94

0.78 to 1.13

0.52

0.81

0.74 to 0.90

3.8 × 10 -5

0.20

BRCA2

2,926

1,366

406

1,648

0.97

0.86 to 1.10

0.68

0.78

0.62 to 1.00

0.049

0.12

9q31.2 - rs865686

          

BRCA1

4,892

559

1,888

2,836

0.92

0.81 to 1.03

0.15

1.01

0.95 to 1.08

0.68

0.16

BRCA2

2,924

1,370

405

1,645

0.91

0.84 to 0.99

0.028

1.07

0.92 to 1.25

0.40

0.08

  1. ER, estrogen receptor; HR, hazard ratio
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Breast Cancer Research

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