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Table 7 Multivariate analysis of GP88 and combined risk factors on DFS and OS

From: Progranulin (GP88) tumor tissue expression is associated with increased risk of recurrence in breast cancer patients diagnosed with estrogen receptor positive invasive ductal carcinoma

Covariate DFS OS
  HR CI P HR CI P
GP88 (3+ vs. < 3+) 5.15 2.73 to 9.69 < 0.0001 1.84 1.13 to 3.00 0.0148
Ethnicity (Caucasian vs. non-Caucasian) 1.94 0.94 to 4.04 0.0744 1.03 0.57 to 1.86 0.9190
Age (> 50 yrs vs. ≤ 50 yrs) 0.66 0.34 to 1.30 0.2301 1.57 0.90 to 2.75 0.1101
Tumor size (> 2 cm vs. ≤ 2 cm) 1.06 0.50 to 2.23 0.8793 1.03 0.61 to 1.72 0.9257
Tumor size (> 5 cm vs. ≤ 5 cm) 0.44 0.09 to 2.29 0.3324 0.79 0.25 to 2.54 0.6979
Grade (> 1 vs. ≤ 1) 0.70 0.09 to 5.50 0.7309 0.54 0.16 to 1.86 0.3291
Grade (> 2 vs. ≤ 2) 0.80 0.41 to 1.57 0.5130 1.72 1.00 to 2.94 0.0501
Stage (> 1 vs. ≤ 1) 1.45 0.59 to 3.56 0.4211 2.52 1.23 to 5.14 0.0111
Stage (> 2 vs. ≤ 2) 4.21 1.78 to 9.93 0.0010 2.42 1.28 to 4.57 0.0065
  1. Multivariate analysis determined the association of GP88 score with all other combined clinical risk factors on DFS and OS.
  2. CI, 95% confidence interval; DFS, disease-free survival; HR, hazard ratio; OS, overall survival