Figure 3From: Contribution of CXCL12 secretion to invasion of breast cancer cellsMotility in the tumor microenvironment. Intravital imaging (IVI) using multiphoton microscopy of primary mammary tumors from transgenic Neu deletion mutant (activated receptor) (Neu-NDL), Neu-YD and Neu-YB cyan fluorescent protein mice. Thirty-minute time-lapse Z-series were collected, and the average total cell motility was quantified per 50-μm Z-stack (five sections imaged at 10-μm intervals). Data are means and SEM of 27 to 32 separate Z-stacks. *P < 0.05, **P < 0.005 by Mann-Whitney U test; n = 13 Neu-NDL mice, n = 8 Neu-YD mice and n = 12 Neu-YB mice.Back to article page