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Table 2 Relative risks of total breast cancers based on Singapore Breast Cancer Screening Project cohort by risk factors in Gail model

From: Validation of the Gail model for predicting individual breast cancer risk in a prospective nationwide study of 28,104 Singapore women

Risk factors Based on SBCSP (95% CI) Gail model: BCDDP (95% CI)
Age at menarche, years   
   ≥14 1.00 (referent) 1.00 (referent)
   12-13 1.39 1.10
   < 12 1.95 1.21
Any breast biopsy
Age at screening: ≥50 years
  
   No 1.00 (referent) 1.00 (referent)
   Yes 1.97 1.28a
Number of affected first-degree relatives
Age at first live birth: < 20 years
  
   0 1.00 (referent) 1.00 (referent)
   1 3.61 2.61
   > 1 13.04 6.80
Number of affected first-degree relatives
Age at first live birth: 20-24 years
  
   0 1.33 1.24
   1 4.14 2.68
   > 1 12.91 5.78
Number of affected first-degree relatives
Age at first live birth: 25-29 years or nulliparous
  
   0 1.76 1.55
   1 4.75 2.76
   > 1 12.79 4.91
Number of affected first-degree relatives
Age at first live birth: > 30 years
  
   0 2.34 1.93
   1 5.44 2.83
   > 1 12.67 4.17
  1. aDerived from Decarli and colleagues [23] (2006). BCDDP, Breast Cancer Detection Demonstration Project; CI, confidence interval; SBCSP, Singapore Breast Cancer Screening Project.