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Table 1 Tumorigenic potential of CD44/Sca1-positive cells

From: Metastasis is an early event in mouse mammary carcinomas and is associated with cells bearing stem cell markers

Sorted donor cells Donor age (days) Numbers of recipient mice Tumor incidence
Tumor (+) cells > 120 4 4/4
Tumor (-) cells > 120 2 0/2
MECs (+) cells < 40 3 3/3
MECs (-) cells < 40 2 0/2
Lung (+) cells > 120 5 5/5
Lung (+) cells < 40 3 3/3
Lung (-) cells > 120 2 0/2
  1. CD44/Sca1 positive (+) and CD44/Sca1 negative (-) cells were obtained by cell sorting from tumor cells, mammary epithelial cells (MECs), or lungs of GFP MMT mice at indicated ages and 8 × 104 cells were injected into the mammary fat pads of wild type mice. Tumor incidence was determined 60 days after cell inoculation.