Table 1 Clinicopathological characteristics of the human patients with breast cancer in this study with STAT1 staining results
From: STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas
Number (percentage) | ||||
|---|---|---|---|---|
All cases | ER- | ER+ | ||
Characteristics | ( n = 161) | ( n = 78) | ( n = 83) | P value |
PR expression | ||||
Negative | 95 (59%) | 78 (100%) | 7 (8%) | 2.91 × 10-38a |
Positive | 76 (47%) | 0 (0%) | 76 (92%) | |
HER2 IHC or FISH | ||||
Negative | 129 (80%) | 46 (59%) | 83 (100%) | 1.35 × 10-12a |
Positive | 32 (20%) | 32 (41%) | 0 (0%) | |
Histology groupb | ||||
A | 6 (4%) | 2 (3%) | 4 (5%) | |
B | 138 (85%) | 71 (91%) | 67 (81%) | 0.2512a |
C | 16 (10%) | 5 (6%) | 11 (13%) | |
D | 1 (1%) | 0 (0%) | 1 (1%) | |
Percentage of STAT1+ neoplastic cells (percentage score) | ||||
< 5% | 17 (11%) | 7 (9%) | 10 (12%) | |
5%-25% | 20 (12%) | 10 (13%) | 10 (12%) | 0.91c |
26%-75% | 65 (40%) | 33 (42%) | 32 (39%) | |
> 75% | 59 (37%) | 28 (36%) | 31 (37%) | |
Percentage of STAT1+ stromal cells (percentage score) | ||||
< 5% | 0 (0%) | 0 (0%) | 0 (0%) | |
5%-25% | 16 (10%) | 2 (3%) | 14 (17%) | 0.006a |
26%-75% | 54 (34%) | 26 (33%) | 28 (34%) | |
> 75% | 91 (56%) | 50 (64%) | 41 (49%) | |
STAT1 intensity in STAT1+ neoplastic cells (intensity score) | ||||
Low | 54 (34%) | 17 (22%) | 37 (45%) | |
Intermediate | 60 (37%) | 31 (40%) | 29 (35%) | 0.0042c |
High | 47 (29%) | 30 (38%) | 17 (20%) | |
STAT1 intensity in STAT1+ stromal cells (intensity score) | ||||
Low | 2 (1%) | 0 (0%) | 2 (2%) | |
Intermediate | 18 (11%) | 3 (4%) | 15 (18%) | 0.0027a |
High | 141 (88%) | 75 (96%) | 66 (80%) | |