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Table 1 Clinicopathological characteristics of the human patients with breast cancer in this study with STAT1 staining results

From: STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas

  Number (percentage)  
  All cases ER- ER+  
Characteristics ( n = 161) ( n = 78) ( n = 83) P value
PR expression     
   Negative 95 (59%) 78 (100%) 7 (8%) 2.91 × 10-38a
   Positive 76 (47%) 0 (0%) 76 (92%)  
HER2 IHC or FISH     
   Negative 129 (80%) 46 (59%) 83 (100%) 1.35 × 10-12a
   Positive 32 (20%) 32 (41%) 0 (0%)  
Histology groupb     
   A 6 (4%) 2 (3%) 4 (5%)  
   B 138 (85%) 71 (91%) 67 (81%) 0.2512a
   C 16 (10%) 5 (6%) 11 (13%)  
   D 1 (1%) 0 (0%) 1 (1%)  
Percentage of STAT1+ neoplastic cells (percentage score)     
   < 5% 17 (11%) 7 (9%) 10 (12%)  
   5%-25% 20 (12%) 10 (13%) 10 (12%) 0.91c
   26%-75% 65 (40%) 33 (42%) 32 (39%)  
   > 75% 59 (37%) 28 (36%) 31 (37%)  
Percentage of STAT1+ stromal cells (percentage score)     
   < 5% 0 (0%) 0 (0%) 0 (0%)  
   5%-25% 16 (10%) 2 (3%) 14 (17%) 0.006a
   26%-75% 54 (34%) 26 (33%) 28 (34%)  
   > 75% 91 (56%) 50 (64%) 41 (49%)  
STAT1 intensity in STAT1+ neoplastic cells (intensity score)     
   Low 54 (34%) 17 (22%) 37 (45%)  
   Intermediate 60 (37%) 31 (40%) 29 (35%) 0.0042c
   High 47 (29%) 30 (38%) 17 (20%)  
STAT1 intensity in STAT1+ stromal cells (intensity score)     
   Low 2 (1%) 0 (0%) 2 (2%)  
   Intermediate 18 (11%) 3 (4%) 15 (18%) 0.0027a
   High 141 (88%) 75 (96%) 66 (80%)  
  1. aFisher exact test. bHistology group A: ductal carcinoma in situ with minor areas of invasive ductal carcinoma; group B: invasive ductal carcinoma; group C: lobular carcinomas; group D: mixed ductal and lobular carcinomas. cChi-squared test. ER, estrogen receptor; FISH, fluoresence in situ hybridization; HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; PR, progesterone receptor.