Table 3 Hazard ratios for different Ki-67LI cut-off points for BCSS and DMFS in luminal and HER⁺ training sets

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

10%

< 0.001

4.289 (3.043-6.045)

< 0.001

2.951 (2.233-3.901)

0.439

1.314 (0.658-2.625)

0.401

1.334 (0.674-2.682)

13%

3.484 (2.580-4.704)

2.595 (2.006-3.356)

0.647

0.883 (0.519-1.503)

0.758

0.920 (0.541-1.536)

17%

3.387 (2.547-4.506)

2.468 (1.923-3.166)

0.318

0.780 (0.480-1.270)

0.368

0.800 (0.493-1.299)

20%

3.555 (2.683-4.712)

2.578 (2.012-3.304)

0.367

0.805 (0.502-1.291)

0.457

0.837 (0.523-1.339)

25%

3.091 (2.348-4.069)

2.458 (1.918-3.150)

0.355

0.810 (0.519-1.265)

0.483

0.854 (0.549-1.328)

30%

3.004 (2.283-3.954)

2.415 (1.880-3.101)

0.717

0.923 (0.596-1.427)

0.824

0.952 (0.617-1.468)

35%

3.182 (2.413-4.195)

2.648 (2.055-3.413)

0.698

1.089 (0.708-1.675)

0.723

1.080 (0.706-1.652)

10% and 50%:

0.191

0.334

Moderate vs. low

3.473 (2.421-4.983)

2.483 (1.847-3.336)

0.747

1.126 (0.547-2.319)

0.611

1.205 (0.588-2.469)

High vs. low

7.648 (5.116-11.43)

5.021 (3.533-7.134)

0.188

1.638 (0.786-3.414)

0.220

1.586 (0.759-3.313)