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Figure 2 | Breast Cancer Research

Figure 2

From: Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cells

Figure 2

Acquisition of resistance to docetaxel or paclitaxel in MCF-7 cells. Sensitivity of MCF-7CC cells (broken lines) and taxane-selected MCF-7 cells (solid lines) was measured after selection for survival to dose levels 8 (MCF-7TXT8), 9 (MCF-7TXT9), 10 (MCF-7TXT10), 11 (MCF-7TXT11), or 12 (MCF-7TXT12), or at the maximally tolerated dose of paclitaxel (MCF-7TAX-1 cells). Mean survival fractions (± standard error) are plotted, and the significance of differences in docetaxel sensitivity between the taxane-selected and control cell lines was assessed by using a Student t test (n = 5); P values of < 0.05, < 0.01, and < 0.001 are represented by the *, **, and *** symbols, respectively.

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Breast Cancer Research

ISSN: 1465-542X

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