Figure 8

Evaluation of PTEN gene expression in primary tumors with outcome at 5 years in Harrell et al. [19] combined data set. (a) Relapse-free survival in the entire data set (n = 855) based on PTEN expression. (b) Time to brain recurrence (as the first site of relapse) based on PTEN expression in the subset of patients that relapse to the brain in the first 5 years (n = 42). In both survival analyses, tumors in the highest PTEN expression tertile of the entire data set were identified as high PTEN expressers, and the rest, as low PTEN expressers. P values shown here have been adjusted for ER status and intrinsic molecular subtype.