Table 4 CSC marker associations with molecular subtype and Ki67
From: Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance
| Â | Â | ER POSITIVE | ER NEGATIVE | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variable | Â | CD44+CD24-/low | ALDH1A1 | ALDH1A3 | ITGA6 | CD44+CD24-/low | ALDH1A1 | ALDH1A3 | ITGA6 | ||||||||
| Â | Â | Negative | Positive | Negative | Positive | Negative | Positive | Negative | Positive | Negative | Positive | Negative | Positive | Negative | Positive | Negative | Positive |
Molecular subtype | Luminal 1a | 1050 (83) | 205 (75) | 1, 331 (81) | 28 (72) | 1, 232 (81) | 40 (59) | 1, 045 (80) | 41 (82) | 60 (17) | 9 (7) | 75 (16) | 2 (4) | 71 (17) | 2 (4) | 62 (17) | 8 (10) |
| Â | Other | 219 (17) | 69 (25) | 307 (19) | 11 (28) | 283 (19) | 28 (41) | 257 (20) | 9 (18) | 292 (83) | 120 (93) | 408 (84) | 43 (96) | 359 (83) | 54 (96) | 294 (83) | 69 (90) |
| Â | P-value | 0.002 | 0.136 | < 0.001 | 0.761 | 0.005 | 0.046* | 0.009* | 0.129 | ||||||||
| Â | Luminal 1b | 96 (8) | 49 (18) | 156 (10) | 6 (15) | 152 (10) | 11 (16) | 128 (10) | 4 (8) | 12 (3) | 5 (4) | 17 (4) | 2 (4) | 15 (3) | 2 (4) | 8 (2) | 5 (6) |
| Â | Other | 1173 (92) | 225 (82) | 1482 (90) | 33 (85) | 1363 (90) | 57 (84) | 1174 (90) | 46 (92) | 340 (97) | 124 (96) | 466 (96) | 43 (96) | 415 (97) | 54 (96) | 348 (98) | 72 (94) |
| Â | P-value | < 0.001 | 0.221 | 0.103 | 0.812* | 0.806 | 0.672* | 1.000* | 0.062* | ||||||||
| Â | Luminal 2 | 123 (10) | 20 (7) | 151 (9) | 5 (13) | 131 (9) | 17 (25) | 129 (10) | 5 (10) | 13 (4) | 3 (2) | 16 (3) | 2 (4) | 14 (3) | 2 (4) | 16 (4) | 1 (1) |
| Â | Other | 1, 146 (90) | 254 (93) | 1, 487 (91) | 34 (87) | 1, 384 (91) | 51 (75) | 1, 173 (90) | 45 (90) | 339 (96) | 126 (98) | 467 (97) | 43 (96) | 416 (97) | 54 (96) | 340 (96) | 76 (99) |
| Â | P-value | 0.215 | 0.444 | < 0.001 | 0.983 | 0.576* | 0.660* | 0.705* | 0.329* | ||||||||
| Â | HER2 | NA | NA | NA | NA | 81 (23) | 14 (11) | 86 (18) | 17 (38) | 83 (19) | 14 (25) | 76 (21) | 12 (16) | ||||
| Â | Other | Â | Â | Â | Â | Â | Â | Â | Â | 271 (77) | 115 (89) | 397 (82) | 28 (62) | 347 (81) | 42 (75) | 280 (79) | 65 (84) |
| Â | P-value | Â | Â | Â | Â | Â | Â | Â | Â | 0.003 | 0.001 | 0.316 | 0.254 | ||||
| Â | CBP | NA | NA | NA | NA | 118 (34) | 68 (53) | 180 (37) | 18 (40) | 164 (38) | 23 (41) | 122 (34) | 35 (45) | ||||
| Â | Other | Â | Â | Â | Â | Â | Â | Â | Â | 234 (66) | 61 (47) | 303 (63) | 27 (60) | 266 (62) | 33 (59) | 234 (66) | 42 (55) |
| Â | P-value | Â | Â | Â | Â | Â | Â | Â | Â | < 0.001 | 0.717 | 0.671 | 0.064 | ||||
| Â | 5NP | NA | NA | NA | NA | 68 (19) | 30 (23) | 109 (23) | 4 (9) | 83 (19) | 13 (23) | 72 (20) | 16 (21) | ||||
| Â | Other | Â | Â | Â | Â | Â | Â | Â | Â | 284 (81) | 99 (77) | 374 (77) | 41 (91) | 347 (81) | 43 (77) | 284 (80) | 61 (79) |
| Â | P-value | Â | Â | Â | Â | Â | Â | Â | Â | 0.342 | 0.035* | 0.489 | 0.913 | ||||
Ki67 | Negative | 1, 037 (77) | 220 (77) | 1, 370 (78) | 27 (66) | 1, 243 (78) | 41 (61) | 1, 088 (78) | 37 (70) | 196 (50) | 52 (37) | 262 (49) | 13 (27) | 232 (48) | 23 (39) | 200 (50) | 30 (34) |
| Â | Positive | 305 (23) | 65 (23) | 386 (22) | 14 (34) | 360 (22) | 26 (39) | 308 (22) | 16 (30) | 197 (50) | 90 (63) | 276 (51) | 36 (73) | 255 (52) | 36 (61) | 198 (50) | 58 (66) |
| Â | P-value | 0.977 | 0.064 | 0.002 | 0.163 | 0.007 | 0.003 | 0.208 | 0.006 | ||||||||