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Table 1 Genes differentially regulated by IRF5 in MDA-MB-231 cells.

From: Loss of interferon regulatory factor 5 (IRF5) expression in human ductal carcinoma correlates with disease stage and contributes to metastasis

Gene Function Expression in pBIRF5 vs. pBabe
CTSK a Cathepsin K Decreased
CXCR4 b Receptor for CXCL12/SDF-1 Decreased
HGF a Hepatocyte growth factor Decreased
ITGA7 b Integrinα7 Decreased
MMP10 a Matrix metalloproteinase 10 Decreased
MMP3 b Matrix metalloproteinase 3 Increased
RORB b Retinoid-related orphan receptor β Increased
  1. adenotes genes with ≥ 2- to 3.99-fold change; bgenes with ≥ 4- to 6.99-fold change. Gene expression was compared between MDA-MB-231/pBabe and MDA-MB-231/pBIRF5.