Loss of interferon regulatory factor 5 (IRF5) expression in human ductal carcinoma correlates with disease stage and contributes to metastasis

Table 1 Genes differentially regulated by IRF5 in MDA-MB-231 cells.

Gene	Function	Expression in pBIRF5 vs. pBabe
CTSK ^a	Cathepsin K	Decreased
CXCR4 ^b	Receptor for CXCL12/SDF-1	Decreased
HGF ^a	Hepatocyte growth factor	Decreased
ITGA7 ^b	Integrinα7	Decreased
MMP10 ^a	Matrix metalloproteinase 10	Decreased
MMP3 ^b	Matrix metalloproteinase 3	Increased
RORB ^b	Retinoid-related orphan receptor β	Increased

^adenotes genes with ≥ 2- to 3.99-fold change; ^bgenes with ≥ 4- to 6.99-fold change. Gene expression was compared between MDA-MB-231/pBabe and MDA-MB-231/pBIRF5.

ISSN: 1465-542X