Table 3 Genotype and per-allele hazard ratio estimates by estrogen receptor status for BRCA2 mutation carriers

FGFR2 rs2981582

GG

794 (37.8)

86 (32.7)

248 (29.5)

457 (29.8)

1.00

1.00

GA

987 (47.0)

137 (52.1)

419 (49.8)

755 (49.3)

1.28

0.99 to 1.67

1.35

1.17 to 1.55

AA

321 (15.3)

40 (15.2)

174 (20.7)

320 (20.9)

1.23

0.85 to 1.78

1.81

1.51 to 2.18

Per-allele

1.14

0.97 to 1.35

0.12

1.35

1.23 to 1.48

1.4 × 10 ^-10

0.097

TOX3/TNRC9 rs3803662

CC

1,088 (53.4)

136 (53.3)

377 (46.3)

702 (48.2)

1.00

1.00

CT

792 (38.9)

96 (37.7)

361 (44.3)

604 (41.5)

0.98

0.75 to 1.27

1.33

1.17 to 1.53

TT

157 (7.7)

23 (9.0)

77 (9.5)

150 (10.3)

1.27

0.83 to 1.93

1.54

1.22 to 1.95

Per-allele

1.06

0.88 to 1.29

0.53

1.28

1.16 to 1.41

1.5 × 10 ^-6

0.11

MAP3K1 rs889312

AA

1,107 (51.1)

121 (45.7)

430 (50.3)

746 (47.7)

1.00

1.00

AC

888 (41.0)

120 (45.3)

349 (40.8)

646 (41.3)

1.23

0.96 to 1.59

1.03

0.90 to 1.17

CC

170 (7.9)

24 (9.1)

76 (8.9)

172 (11.0)

1.42

0.93 to 2.16

1.29

1.03 to 1.62

Per-allele

1.21

1.01 to 1.45

0.039

1.09

0.99 to 1.21

0.08

0.35

LSP1 rs3817198

TT

1,075 (46.1)

142 (44.4)

429 (42.0)

718 (42.7)

1.00

1.00

TC

1,005 (43.1)

146 (45.6)

466 (45.6)

759 (45.2)

1.08

0.86 to 1.36

1.14

1.01 to 1.29

CC

252 (10.8)

32 (10.0)

127 (12.4)

203 (12.1)

1.02

0.68 to 1.51

1.39

1.14 to 1.70

Per-allele

1.03

0.87 to 1.22

0.70

1.17

1.07 to 1.28

5.5 × 10 ^-4

0.20

2q35 rs13387042

GG

571 (25.3)

71 (23.0)

216 (22.0)

382 (23.1)

1.00

1.00

GA

1,080 (47.8)

156 (50.5)

500 (50.8)

809 (48.8)

1.12

0.85 to 1.47

1.18

1.01 to 1.36

AA

608 (26.9)

82 (26.5)

268 (27.2)

466 (28.1)

1.06

0.78 to 1.45

1.13

0.95 to 1.34

Per-allele

1.03

0.87 to 1.19

0.71

1.06

0.97 to 1.15

0.20

0.75

8q24 rs13281615

AA

794 (34.1)

99 (31.6)

317 (31.7)

524 (31.3)

1.00

1.00

AG

1,156 (49.6)

165 (52.7)

511 (51.1)

837 (49.9)

1.08

0.85 to 1.38

1.05

0.92 to 1.21

GG

382 (16.4)

49 (15.7)

172 (17.2)

315 (18.8)

1.05

0.75 to 1.46

1.13

0.94 to 1.35

Per-allele

1.04

0.89 to 1.21

0.66

1.06

0.97 to 1.16

0.19

0.80

SLC4A7/NEK10 rs4973768

CC

669 (26.5)

82 (24.9)

251 (22.6)

401 (23.5)

1.00

1.00

CT

1,241 (49.1)

164 (49.9)

546 (49.4)

829 (48.7)

1.05

0.81 to 1.36

1.14

0.99 to 1.31

TT

618 (24.5)

83 (25.2)

311 (28.0)

474 (27.8)

1.04

0.77 to 1.41

1.27

1.08 to 1.50

Per-allele

1.02

0.88 to 1.19

0.78

1.13

1.04 to 1.22

0.0043

0.25

STXBP4/COX11 rs6504950

GG

1,420 (55.6)

171 (51.0)

601 (53.1)

896 (52.5)

1.00

1.00

GA

951 (37.2)

145 (43.3)

444 (39.3)

684 (40.1)

1.27

1.03 to 1.58

1.09

0.97 to 1.23

AA

184 (7.2)

19 (5.7)

86 (7.6)

127 (7.4)

0.84

0.54 to 1.30

1.08

0.87 to 1.34

Per-allele

1.07

0.92 to 1.25

0.36

1.06

0.97 to 1.16

0.19

0.91

5p12 rs10941679

AA

1,372 (58.6)

176 (54.8)

584 (54.8)

924 (56.3)

1.00

1.00

AG

824 (35.2)

122 (38.0)

425 (39.9)

622 (37.9)

1.08

0.86 to 1.37

1.15

1.01 to 1.30

GG

146 (6.2)

23 (7.2)

57 (5.4)

94 (5.7)

1.25

0.82 to 1.91

0.94

0.73 to 1.22

Per-allele

1.10

0.92 to 1.31

0.28

1.06

0.96 to 1.17

0.23

0.70

6q25.1 - rs2046210

CC

985 (39.8)

121 (39.2)

466 (42.1)

634 (37.7)

1.00

1.00

TC

1,165 (47.1)

132 (42.7)

499 (45.1)

802 (47.7)

0.99

0.78 to 1.12

0.96

0.85 to 1.08

TT

324 (13.1)

56 (18.1)

141 (12.8)

247 (14.7)

1.47

1.08 to 2.01

0.94

0.78 to 1.12

Per-allele

1.17

0.99 to 1.38

0.059

0.97

0.89 to 1.05

0.41

0.045

1p11.2 - rs11249433

TT

895 (35.9)

107 (33.6)

345 (31.4)

599 (34.7)

1.00

1.00

CT

1,226 (49.2)

160 (50.3)

553 (50.3)

843 (48.9)

1.00

0.79 to 1.28

0.96 to 1.23

CC

371 (14.9)

51 (16.0)

202 (18.4)

282 (16.4)

1.00

0.73 to 1.40

1.27

1.08 to 1.50

Per-allele

1.00

0.86 to 1.17

0.98

1.12

1.03 to 1.22

0.0065

0.23

RAD51L1 - rs999737/rs10483813

BRCA1

1,368 (59.5)

167 (59.0)

589 (61.4)

1,000 (62.0)

1.00

1.00

TC/AT

789 (34.3)

104 (36.8)

323 (33.6)

534 (33.1)

1.06

0.84 to 1.35

0.94

0.83 to 1.07

TT/AA

141 (6.1)

12 (4.2)

48 (5.0)

80 (4.9)

0.74

0.42 to 1.32

0.87

0.67 to 1.14

Per-allele

0.97

0.80 to 1.17

0.73

0.94

0.85 to 1.03

0.20

0.77