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Table 4 Combined effect of dense and fat tissue on breast cancer risk

From: Mammographic density and breast cancer risk: the role of the fat surrounding the fibroglandular tissue

  N Case/Control Dense area
(min.-max.)
Non-dense area
(min.-max.)
Median breast size Median percent density OR*; 95% CI OR**; 95% CI
Low Dense - Low Non-Dense 41/138 0.8-14.9 cm2 38.3-116.3 cm2 102.9 cm2 9.34% Ref. Ref.
Low Dense - High Non-Dense 102/291 0.3-14.7 cm2 116.4-289.6 cm2 164.6 cm2 3.54% 1.18; 0.78-1.85 1.02; 0.64-1.63
High Dense - Low Non-Dense 129/289 15.1-98.2 cm2 12.5-116.1 cm2 115.3 cm2 28.24% 1.58; 1.02-2.44 1.58; 1.02-2.45
High Dense - High Non-Dense 86/139 14.9-99.2 cm2 116.6-258.6 cm2 175.1 cm2 13.69% 2.15; 1.34-3.45 1.84; 1.12-3.02
RERI       0.39; -0.43-1.20 0.24; -0.52-1.00
  1. *Adjusted for age at examination, height, age at menarche, age at first delivery (nulliparous, ≤25 years at first delivery, >25 at first delivery), number of children, age at menopause (premenopausal, ≤50 years at menopause, >50 years at menopause), HT use (never, current, ever), pill use (never, current, ever), family history of breast cancer (yes/no)
  2. **Same as *, but additionally adjusted for BMI
  3. Dense area was split by the median which was 14.9 cm2
  4. Non-dense area was split by the median which was 116.4 cm2