Mammographic density and breast cancer risk: the role of the fat surrounding the fibroglandular tissue

Breast Cancer Research

Table 4 Combined effect of dense and fat tissue on breast cancer risk

	N Case/Control	Dense area (min.-max.)	Non-dense area (min.-max.)	Median breast size	Median percent density	OR; 95% CI*	OR; 95% CI
Low Dense^† - Low Non-Dense^‡	41/138	0.8-14.9 cm²	38.3-116.3 cm²	102.9 cm²	9.34%	Ref.	Ref.
Low Dense - High Non-Dense	102/291	0.3-14.7 cm²	116.4-289.6 cm²	164.6 cm²	3.54%	1.18; 0.78-1.85	1.02; 0.64-1.63
High Dense - Low Non-Dense	129/289	15.1-98.2 cm²	12.5-116.1 cm²	115.3 cm²	28.24%	1.58; 1.02-2.44	1.58; 1.02-2.45
High Dense - High Non-Dense	86/139	14.9-99.2 cm²	116.6-258.6 cm²	175.1 cm²	13.69%	2.15; 1.34-3.45	1.84; 1.12-3.02
RERI						0.39; -0.43-1.20	0.24; -0.52-1.00

*Adjusted for age at examination, height, age at menarche, age at first delivery (nulliparous, ≤25 years at first delivery, >25 at first delivery), number of children, age at menopause (premenopausal, ≤50 years at menopause, >50 years at menopause), HT use (never, current, ever), pill use (never, current, ever), family history of breast cancer (yes/no)
**Same as *, but additionally adjusted for BMI
^†Dense area was split by the median which was 14.9 cm²
^‡Non-dense area was split by the median which was 116.4 cm²

ISSN: 1465-542X