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Table 4 Combined effect of dense and fat tissue on breast cancer risk

From: Mammographic density and breast cancer risk: the role of the fat surrounding the fibroglandular tissue

 

N Case/Control

Dense area

(min.-max.)

Non-dense area

(min.-max.)

Median breast size

Median percent density

OR*; 95% CI

OR**; 95% CI

Low Dense - Low Non-Dense

41/138

0.8-14.9 cm2

38.3-116.3 cm2

102.9 cm2

9.34%

Ref.

Ref.

Low Dense - High Non-Dense

102/291

0.3-14.7 cm2

116.4-289.6 cm2

164.6 cm2

3.54%

1.18; 0.78-1.85

1.02; 0.64-1.63

High Dense - Low Non-Dense

129/289

15.1-98.2 cm2

12.5-116.1 cm2

115.3 cm2

28.24%

1.58; 1.02-2.44

1.58; 1.02-2.45

High Dense - High Non-Dense

86/139

14.9-99.2 cm2

116.6-258.6 cm2

175.1 cm2

13.69%

2.15; 1.34-3.45

1.84; 1.12-3.02

RERI

     

0.39; -0.43-1.20

0.24; -0.52-1.00

  1. *Adjusted for age at examination, height, age at menarche, age at first delivery (nulliparous, ≤25 years at first delivery, >25 at first delivery), number of children, age at menopause (premenopausal, ≤50 years at menopause, >50 years at menopause), HT use (never, current, ever), pill use (never, current, ever), family history of breast cancer (yes/no)
  2. **Same as *, but additionally adjusted for BMI
  3. Dense area was split by the median which was 14.9 cm2
  4. Non-dense area was split by the median which was 116.4 cm2