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Table 3 Breast tissue measures and breast cancer risk

From: Mammographic density and breast cancer risk: the role of the fat surrounding the fibroglandular tissue

Quintiles N (Case/Controle) Median (%)
(IQR)
OR (95% CI)* OR (95% CI)** OR
(95% CI)***
OR (95% CI)****
Percent Density       
1 53/171 2.2 (1.5 to 3.0) Ref Ref   
2 61/171 5.8 (4.8 to 7.0) 1.4 (0.9 to 2.3) 1.6 (1.0 to 2.5)   
3 88/172 11.4 (10.0 to 13.4) 1.8 (1.1 to 3.3) 2.1 (1.3 to 3.3)   
4 88/173 20.3 (18.1 to 23.5) 2.1 (1.6 to 3.4) 2.5 (1.6 to 4.1)   
5 68/172 38.9 (38.9 to 48.9) 1.4 (1.0 to 2.9) 1.8 (1.0 to 2.9)   
P-trend    0.029 0.002   
Dense Area   Median (cm 2 )
(IQR)
    
1 46/172 3.6 (2.3 to 4.6) Ref Ref Ref Ref
2 55/172 8.3 (6.9 to 9.5) 1.3 (0.8 to 2.1) 1.4 (0.9 to 2.4) 1.5 (0.9 to 2.4) 1.5 (0.9 to 2.4)
3 86/171 14.9 (12.6 to 16.8) 2.1 (1.3 to 3.3) 2.3 (1.4 to 3.7) 2.6 (1.6 to 4.2) 2.6 (1.6 to 4.2)
4 93/172 25.5 (22.6 to 29.3) 2.4 (1.5 to 3.8) 2.6 (1.7 to 4.2) 3.2 (2.0 to 5.3) 3.2 (2.0 to 5.3)
5 78/172 44.4 (39.5 to 54.4) 1.9 (1.1 to 3.0) 2.1 (1.3 to 3.4) 2.9 (1.7 to 4.9) 2.8 (1.7 to 4.8)
P-trend    0.001 <0.001 <0.001 <0.001
Non Dense Area   Median (cm 2 )
(IQR)
    
1 65/172 61.0 (48.2 to 69.9) Ref Ref Ref Ref
2 61/171 90.5 (84.2 to 96.5) 1.0 (0.6 to 1.5) 0.9 (0.6 to 1.5) 1.1(0.7 to 1.8) 1.1 (0.7 to 1.8)
3 72/172 115.5 (109.4 to 121.3) 1.2 (0.8 to 1.9) 1.2 (0.7 to 1.8) 1.6 (1.0 to 2.5) 1.5 (0.9 to 2.4)
4 65/173 141.7 (133.2 to 148.9) 1.0 (0.6 to 1.6) 0.9 (0.6 to 1.5) 1.4 (0.9 to 2.3) 1.4 (0.8 to 2.3)
5 95/171 186.7 (172.1 to 211.8) 1.7 (1.1 to 2.5) 1.4 (0.9 to 2.4) 2.6 (1.6 to 4.2) 2.4 (1.3 to 4.2)
P-trend    0.009 0.115 <0.001 <0.001
  1. * Potential confounders
  2. ** Potential confounders and BMI
  3. *** Potential confounders and Breast Tissue ( Adjusted for Non-Dense Area, Adjusted for Dense Area)
  4. **** Potential confounders, BMI and Breast Tissue ( Adjusted for Non-Dense Area, Adjusted for Dense Area)
  5. Potential confounders: Age at mammography, Height, Age at Menarche, Age First Delivery (Nulliparous, ≤25 years at first delivery, >25 years at first delivery), Nr. of children, Age Menopause (Premenopausal, ≤50 years at menopause, >50 years at menopause), HT use (Never, Current, Ever), Pill use (Never, Current, Ever), Family History (No/Yes).