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Table 3 Breast tissue measures and breast cancer risk

From: Mammographic density and breast cancer risk: the role of the fat surrounding the fibroglandular tissue

Quintiles

N (Case/Controle)

Median (%)

(IQR)

OR (95% CI)*

OR (95% CI)**

OR

(95% CI)***

OR (95% CI)****

Percent Density

      

1

53/171

2.2 (1.5 to 3.0)

Ref

Ref

  

2

61/171

5.8 (4.8 to 7.0)

1.4 (0.9 to 2.3)

1.6 (1.0 to 2.5)

  

3

88/172

11.4 (10.0 to 13.4)

1.8 (1.1 to 3.3)

2.1 (1.3 to 3.3)

  

4

88/173

20.3 (18.1 to 23.5)

2.1 (1.6 to 3.4)

2.5 (1.6 to 4.1)

  

5

68/172

38.9 (38.9 to 48.9)

1.4 (1.0 to 2.9)

1.8 (1.0 to 2.9)

  

P-trend

  

0.029

0.002

  

Dense Area

 

Median (cm 2 )

(IQR)

    

1

46/172

3.6 (2.3 to 4.6)

Ref

Ref

Ref

Ref

2

55/172

8.3 (6.9 to 9.5)

1.3 (0.8 to 2.1)

1.4 (0.9 to 2.4)

1.5 (0.9 to 2.4)

1.5 (0.9 to 2.4)

3

86/171

14.9 (12.6 to 16.8)

2.1 (1.3 to 3.3)

2.3 (1.4 to 3.7)

2.6 (1.6 to 4.2)

2.6 (1.6 to 4.2)

4

93/172

25.5 (22.6 to 29.3)

2.4 (1.5 to 3.8)

2.6 (1.7 to 4.2)

3.2 (2.0 to 5.3)

3.2 (2.0 to 5.3)

5

78/172

44.4 (39.5 to 54.4)

1.9 (1.1 to 3.0)

2.1 (1.3 to 3.4)

2.9 (1.7 to 4.9)

2.8 (1.7 to 4.8)

P-trend

  

0.001

<0.001

<0.001

<0.001

Non Dense Area

 

Median (cm 2 )

(IQR)

    

1

65/172

61.0 (48.2 to 69.9)

Ref

Ref

Ref

Ref

2

61/171

90.5 (84.2 to 96.5)

1.0 (0.6 to 1.5)

0.9 (0.6 to 1.5)

1.1(0.7 to 1.8)

1.1 (0.7 to 1.8)

3

72/172

115.5 (109.4 to 121.3)

1.2 (0.8 to 1.9)

1.2 (0.7 to 1.8)

1.6 (1.0 to 2.5)

1.5 (0.9 to 2.4)

4

65/173

141.7 (133.2 to 148.9)

1.0 (0.6 to 1.6)

0.9 (0.6 to 1.5)

1.4 (0.9 to 2.3)

1.4 (0.8 to 2.3)

5

95/171

186.7 (172.1 to 211.8)

1.7 (1.1 to 2.5)

1.4 (0.9 to 2.4)

2.6 (1.6 to 4.2)

2.4 (1.3 to 4.2)

P-trend

  

0.009

0.115

<0.001

<0.001

  1. * Potential confounders
  2. ** Potential confounders and BMI
  3. *** Potential confounders and Breast Tissue ( Adjusted for Non-Dense Area, Adjusted for Dense Area)
  4. **** Potential confounders, BMI and Breast Tissue ( Adjusted for Non-Dense Area, Adjusted for Dense Area)
  5. Potential confounders: Age at mammography, Height, Age at Menarche, Age First Delivery (Nulliparous, ≤25 years at first delivery, >25 years at first delivery), Nr. of children, Age Menopause (Premenopausal, ≤50 years at menopause, >50 years at menopause), HT use (Never, Current, Ever), Pill use (Never, Current, Ever), Family History (No/Yes).