Skip to main content

Table 1 Cytotoxic activity of NRC-03 and NRC-07 against normal human cells in comparison to breast cancer cells

From: Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts

 

% Cytotoxicitya

% Hemolysisb

Treatment

HMECs

Fibroblasts

HUVECs

MDA-MB-231

Erythrocytes

25 μM NRC-03

17 ± 5

0 ± 2

3 ± 3

46 ± 6

2 ± 1

50 μM NRC-03

46 ± 3

2 ± 1

19 ± 2

74 ± 4

3 ± 2

25 μM NRC-07

20 ± 4

1 ± 1

7 ± 1

29 ± 8

1 ± 1

50 μM NRC-07

47 ± 9

0 ± 3

17 ± 8

62 ± 5

1 ± 1

  1. a, bMean cytotoxic and hemolytic activity ± SEM (n = 3) of NRC-03 or NRC-07 against cultures of normal primary human cells and MDA-MB-231 breast cancer cells, as well as erythrocytes, was determined as described in the Methods section after 24 hours (HMECs, fibroblasts, HUVECs, and erythrocytes) and 8 hours (MDA-MB-231) of exposure to the peptide.
Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us