Figure 2

NRC-03 and NRC-07 enhance cisplatin-mediated cytotoxicity. MDA-MB-231 cells were cultured in increasing concentrations of cisplatin in the absence or presence of 10 μM NRC-03 or NRC-07. Cell viability, which was used to determine the EC₅₀ of cisplatin, was determined with MTT assay after 72 and 96 hours. The EC₅₀ of NRC-03 and NRC-07 for MDA-MB-231 cells was determined to be 18.7 ± 2.9 and 18.5 ± 0.9, respectively, across multiple experiments. Data are statistically significant by the Bonferroni multiple comparisons test in comparison with cisplatin-treated cells; *p < 0.05. All data shown are the mean of at least three independent experiments ± SEM.