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Table 4 Multivariate analysis of EFS according to standard parameters and the combined B-Cell/IL8-metagene in TNBC

From: A clinically relevant gene signature in triple negative and basal-like breast cancer

  

Finding cohort A*

Validation cohort C*

Variable

 

No. of patients†

Hazard ratio

95% CI

P-value‡

No. of patients§

Hazard ratio

95% CI

P-value‡

Lymph node status

LNN vs N1

210 vs 27

0.59

0.31 to 1.12

0.10

43 vs 29

0.40

0.17 to 0.99

0.046

Age

> 50 vs ≤ 50

113 vs 124

0.75

0.48 to 1.17

0.21

48 vs 24

1.68

0.65 to 4.38

0.29

Tumor size

≤ 2 cm vs > 2 cm

71 vs 166

0.73

0.44 to 1.21

0.22

11 vs 61

0.99

0.28 to 3.42

0.98

Histological grading

G3 vs G1 and 2

166 vs 71

1.11

0.68 to 1.81

0.68

59 vs 13

0.53

0.22 to 1.29

0.16

B-Cell/IL8-Signature

Good vs Poor||

78 vs 159

0.38

0.22 to 0.67

0.001

29 vs 43

0.21

0.07 to 0.62

0.005

  1. * Results from multivariate Cox analysis of event free survival in the TNBC finding cohort A and validation cohort C are presented.
  2. † information on all parameters was available for 237 of the 297 TNBC samples with follow up data from the finding cohort A.
  3. ‡ Significant P-values are given in bold
  4. § information on all parameters was available for 72 of the 76 TNBC samples with follow up data from the validation cohort C.
  5. || "Good" refers to high B-Cell metagene together with low IL8 metagene expression compared to all the remaining samples referred as "Poor".
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Breast Cancer Research

ISSN: 1465-542X

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