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Volume 13 Supplement 2

IX Madrid Breast Cancer Conference

  • Poster presentation
  • Open Access

Oestrogen receptor status predicts for local recurrence following wide local excision for breast tumours

  • 1,
  • 1,
  • 1 and
  • 1
Breast Cancer Research201113 (Suppl 2) :P5

https://doi.org/10.1186/bcr3026

  • Published:

Keywords

  • Breast Cancer
  • Oestrogen Receptor
  • Local Recurrence
  • Breast Tumour
  • Strong Predictor

Introduction

Status of the surgical margins following wide local excision for breast cancer remains one of the strongest predictors of local recurrence. In our practice, a margin of 1 mm and more is considered adequate. In this study, we aim to determine whether clinicopathological factors other than surgical margins contribute to the risk of local recurrence.

Methods

A retrospective review was performed of 548 consecutive patients who underwent wide local excision for invasive carcinoma or ductal carcinoma in situ (DCIS) from 1 January 2004 to 31 December 2008. Surgery was not routinely offered to patients with margins of 1 mm or more. All patients with wide local excision received postoperative whole breast irradiation, inclusive of a boost to the tumour bed.

Results

Local recurrence developed in 20% of those with involved margins, as compared with 8.7% of those with close margins, and 5.4% of those with margins of 1 mm and more. Although local recurrence was more likely with an involved or close surgical margin, this reached only borderline significance (P = 0.05). Oestrogen receptor (ER) status was found to be an independent predictor of local recurrence, with ER-negative tumours being three times more likely to recur (P < 0.01, OR = 0.30, 95% CI = 0.13 to 0.66). There was no correlation with a triple-negative phenotype or other clinicopathological factors.

Conclusion

A margin of 1 mm or more appears to be adequate following wide local excision. However, ER status emerged as a stronger predictor for local recurrence and alone remained significant on multivariate analysis.

Authors’ Affiliations

(1)
Tan Tock Seng Hospital, Singapore, Singapore

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