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Volume 13 Supplement 2

IX Madrid Breast Cancer Conference

  • Oral presentation
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Epigenetics of breast cancer

DNA methylation and histone modifications have important roles in normal mammary differentiation and the development of breast cancer. Epigenetically mediated silencing of tumor suppressor coding genes and microRNAs is a hallmark of human breast tumors. CpG island hypermethylation is starting to be used as a biomarker of the disease, such as BRCA1 hypermethylation as a predictor of response to PARP inhibitors. Most importantly, both DNA methylation and histone modifications are new targets for upcoming drugs.

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Esteller, M. Epigenetics of breast cancer. Breast Cancer Res 13 (Suppl 2), O6 (2011).

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