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- Open Access
Improving the validity of breast density assessment
© Eadie et al. 2011
Published: 4 November 2011
As the importance of mammographic density in risk stratification and breast cancer research continues to grow, density assessment must be rigorous. Area-based human visual density assessment will continue until software is fully validated. Locally, having reviewed the literature, we chose two tools and sought to establish that these would give meaningful results in our hands for comparison with other data.
In 50 mammograms, four observers each estimated the percentage dense area, recorded on a 100 mm visual analogue scale (VAS). On a separate occasion, each observer also assigned BIRADS density scores. The process was repeated with a minimum interval of 1 week. Observers were blinded to each others' scores and their own previous scores. Viewing parameters were standardised.
Intra-rater agreement: Observers 1, 2 and 4, intraclass correlation coefficient (ICC) and lower 95% confidence bound all above 0.8 (excellent agreement); below 0.8 for Observer 3. Inter-rater: Observers 2 and 4, ICC = 0.97, 95% CI = 0.95 to 0.98; Observers 1 and 3 with any other, ICC below 0.8.
Intra-rater agreement, ICC for all observers >0.9 with lower confidence bound >0.8. Inter-rater: Observers 2 and 4 and 2 and 3, ICC and lower confidence bound >0.8; all other pairs, <0.8.
Intra-observer and inter-observer agreement in mammo-graphic density assessment varies. Percentage dense area estimation using a VAS appears more reproducible than the BIRADS classification. This simple study enabled selection of the most reliable observers and we recommend that other centres undertaking scientific studies where mammographic density is a relevant variable perform similar audits to maximise outcome measure validity.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.